Table 1.

Consequences on male fertility phenotypes of animal models with missing adipokine or adipokine receptor.

Type	Phenotype	References
ob/ob mice	Testicular atrophy Decrease nuclear volume of Sertoli cells, spermatogonia, and spermatocytes	[40]
ob/ob mice	Infertile Reduction of testis weight, multinucleated spermatids, few spermatozoa, and anormal Leydig cells	[41]
db/db mice	Infertile	[43]
db/db mice	Infertile Impairment of spermatogenesis and sperm motility	[14]
fa/fa rat (Zucker rat)	Alteration in sperm production and sperm DNA damage	[45]
AdipoR2	Seminiferous tubular atrophy with aspermia and reduced testicular weight	[54]
AdipoR2	Decrease of testis weight	[58]