Table 1.
Mass balance results, as percent of applied dose (%) of zolmitriptan into and through ex vivo human dermatomed skin and Strat-M membrane over 5 hours from a single application. Mean ± SE for skin (n=3 donors with 3 replicates/donor) and mean ± SD (6 replicates) for the membrane.
| Parameter |
Mean Zolmitriptan (%) Dermatomed Skin |
Mean Zolmitriptan (%) Strat-M |
|---|---|---|
| Receptor | 85.46 ± 1.36 | 10.55 ± 6.15 |
| Dermis | 0.50 ± 0.04 | - - - |
| Epidermis | 0.43 ± 0.16 | - - - |
| Stratum Corneum | 0.13 ± 0.04 | - - - |
| Surface Wash | 2.57 ± 1.09 | - - - |
| Strat-M Extraction | - - - - | 39.76 ± 19.75 |
| Ti Array | 3.27 ± 0.36 | 52.79 ± 29.28 |
| Total Recovery | 92.35 ± 2.48 | 103.1 ± 9.2 |