Table 2.
Primary endpoint (n = 10) |
Co-primary endpoint (n = 5) |
Secondary endpoint (n = 9) |
Exploratory endpoint(n = 3) |
Other (n = 2) |
||||||
---|---|---|---|---|---|---|---|---|---|---|
n (%) | Ref. | n (%) | Ref. | n (%) | Ref. | n (%) | Ref. | n (%) | Ref. | |
Therapeutic area | ||||||||||
Cardiology | 1 (10) | 19 | 1 (20) | 17 | 2 (22) | 19, 25 | 0 (0) | - | 0 (0) | - |
Diabetes | 3 (30) | 11, 24, 26 | 2 (40) | 12, 28 | 3 (33) | 11, 26, 28 | 0 (0) | - | 1 (50) | 26 |
Sleep | 0 (0) | - | 1 (20) | 21 | 2 (22) | 15, 20 | 0 (0) | - | 0 (0) | - |
Neurology | 1 (10) | 13 | 0 (0) | - | 0 (0) | - | 0 (0) | - | 0 (0) | - |
Reproductive and | 2 (20) | 8, 10 | 0 (0) | - | 0 (0) | - | 0 (0) | - | 0 (0) | - |
peripartum health Orthopedics | 1 (10) | 22 | 0 (0) | - | 1 (11) | 22 | 0 (0) | - | 0 (0) | - |
Pediatrics | 0 (0) | - | 0 (0) | - | 0 (0) | - | 1 (33) | 9 | 0 (0) | - |
Arthritis | 0 (0) | - | 0 (0) | - | 1 (11) | 16 | 0 (0) | - | 0 (0) | - |
Cancer | 0 (0) | - | 1 (20) | 23 | 0 (0) | - | 2 (66) | 14, 18 | 1 (50) | 14 |
Gastroenterology | 1 (10) | 29 | 0 (0) | - | 0 (0) | - | 0 (0) | - | 0 (0) | - |
Nutrition | 1 (10) | 27 | 0 (0) | - | 0 (0) | - | 0 (0) | - | 0 (0) | - |
Mobile outcome category | ||||||||||
Performance outcome | 6 (60) | 8, 10, 13, 19, 22, 27 | 3 (60) | 17, 21, 23 | 6 (67) | 15, 16, 19, 20, 22, 25 | 3 (100) | 9, 14, 18 | 1 (50) | 14 |
Biomarkers | 4 (40) | 11, 24, 26, 29 | 2 (40) | 12, 28 | 3 (33) | 11, 26, 28 | 0 (0) | 1 (50) | 26 | |
Device | ||||||||||
Wearable inertial sensor/accelerometer | 5 (50) | 8, 19, 22, 24, 27 | 4 (80) | 12, 17, 21, 23 | 6 (67) | 15, 16, 19, 20, 22, 25 | 3 (100) | 9, 14, | 1 (50) | 14 |
Biosensor | 4 (40) | 11, 24, 26, 29 | 2 (40) | 12, 28 | 3 (33) | 11, 26, 28 | 0 (0) | 18 | 1 (50) | 26 |
Continuous glucose monitor | 3 (30) | 11, 24, 26 | 2 (40) | 12, 28 | 3 (33) | 11, 26, 28 | 0 (0) | - | 1 (50) | 26 |
Ingestible pH monitor | 1 (10) | 29 | 0 (0) | - | 0 (0) | - | 0 (0) | - | 0 (0) | - |
Pressure sensor and instrumented walkways | 1 (10) | 13 | 0 (0) | - | 0 (0) | - | 0 (0) | - | 0 (0) | - |
Medication adherence monitor | 1 (10) | 10 | 0 (0) | - | 0 (0) | - | 0 (0) | - | 0 (0) | - |