Table 2. Subtype classification of patients with SCA3 and dystonia and their relatives with SCA3.

Family	Patient	SCA3 subtype	Relatives
				SCA3 subtype	Clinical features
1	1	2	aunt	2	A,D, N
			brother	2	bulging eyes, A,D, N, horizontal and vertical ophthalmoplegia
			nephew	2	A
2	2	1	brother	3	A,D, N, vertical ophthalmoplegia
	3	2	cousin	3	A,D, N, tremor, spasticity, fasciculação corpo, sensib. Face and body fasciculations
	4	2	sister	2	bulging eyes, A,D, N, horizontal ophthalmoplegia, face and body fasciculations, Babinski, hyperreflexia, spasticity
			sister	3	bulging eyes, A,D, N, horizontal, Babinski ophthalmoplegia
			cousin	2	A,D, N, horizontal ophthalmoplegia, Babinski, hyperreflexia
			sister	3	bulging eyes, A,D, N, face and body fasciculations
			brother	3	bulging eyes, A,D, N, horizontal ophthalmoplegia, face and body fasciculations, Babinski,
3	5	1	sister	4	bulging eyes, A,D, N, horizontal ophthalmoplegia, parkinsonism, hyperreflexia, spasticity
			brother	2	A,D, N, horizontal ophthalmoplegia l, hyperreflexia, spasticity
			sister	7	bulging eyes, A,D, N, horizontal ophthalmoplegl, fasciculation, parkinsonism, Babinski, hyperreflexia
4	6	1	brother	2	bulging eyes, A,D, N, horizontal ophthalmoplegia, hyperreflexia
			sister	2	bulging eyes, A,D, N, horizontal ophthalmoplegia, hyperreflexia
			brother	2	bulging eyes, A,D, N, Babinski, hyperreflexia
			father	2	bulging eyes, A,D, N, horizontal ophthalmoplegia, fasciculation, hyperreflexia, esspasticity
			brother	3	bulging eyes, A,D, N, horizontal ophthalmoplegia, fasciculation
			sister	2	A,D, N, hyperreflexia
5	7	1	sister	2	A,D, hyperreflexia
6	8	1	brother	2	bulging eyes, A,D, N, horizontal ophthalmoplegia, fasciculation, hyperreflexia
7	9	1	father	2	bulging eyes, A,D, tremor,Babinski, hyperreflexia, spasticity, fasciculation, neurogenic bladder
			brother	2	bulging eyes, A,D, N, horizontal ophthalmoplegia, hyperreflexia, spasticity, fasciculation
8	10	2	cousin	2	bulging eyes, A,D, N, horizontal ophthalmoplegia, hyperreflexia
			brother	1	A,D, N, horizontal ophthalmoplegia, fasciculation, parkinsonism, hyperreflexia, spasticity
			cousin	3	bulging eyes, A,D, N, horizontal ophthalmoplegia, fasciculation, periferic neuropathy
			cousin	2	A,D, N, hyperreflexia
			cousin	2	A,D, N, horizontal ophthalmoplegia
			cousin	6	A,N, horizontal ophthalmoplegia
			cousin	4	bulging eyes, A,D, N, horizontal ophthalmoplegia, parkinsonism, tremor, fasciculation
9	11	1	-	-	-
	12	1	-	-	-
	13	1	-	-	-
	14	1	-	-	-

A Ataxia, D:Disartria, N: Nystagmus