Table 3.

Effect of Study Intervention (Recommended Care plus Disease Management) versus Control Intervention (Recommended Care Alone) on Primary Endpoint and Its Components

Endpoint	Crude Hazard Ratio (95% CI)	Adjusted Hazard Ratio (95% CI)*
		Model 1	Model 2
Time to first COPD hospital admission or death from all causes (primary composite outcome)	0.91 (0.77–1.08)	0.916 (0.77–1.08)	0.94 (0.80–1.12)
Time to death from all causes	0.78 (0.58–1.07)	0.82 (0.60–1.12)	0.82 (0.60–1.13)
Time to first COPD hospital admission	0.94 (0.79–1.12)	0.93 (0.78–1.11)	0.96 (0.80–1.15)

Definition of abbreviations: CI = confidence interval; COPD = chronic obstructive pulmonary disease; GOLD = Global Initiative for Chronic Obstructive Lung Disease; SF-12 = 12-item Short-Form Health Survey.

^*Cox proportional hazard models were adjusted for model 1 (sex, study center, baseline age, cigarette smoking status, and GOLD classification) and model 2 (all covariates included in model 1 plus the baseline score on the SF-12 mental component).