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. 2018 Jan 2;5(4):678–690.e1. doi: 10.1016/j.jcmgh.2017.12.012

Figure 1.

Figure 1

IL-17A production correlates with the severity of atrophic gastritis in TxA23 mice. (A) Representative H&E sections showing the degree of parietal cell atrophy in healthy BALB/c (2 months old), 2-month-old TxA23, and 12-month-old TxA23 mice. Yellow brackets indicate location of high magnification inset image. (B) Immunofluorescent staining with anti–VEGF-B (green), anti-CD44v9 (red), and Hoechst (blue) to illustrate the extent of parietal cell atrophy and SPEM development in healthy mice, mice early in disease, and mice with advanced disease. (C) Representative flow cytometry plots showing the percentage of IL-17A+ cells in the gastric lymph nodes of young and aged TxA23 mice. (D) The means ± SEM showing significantly higher percentages of IL-17A+ cells in older TxA23 mice compared with younger mice. (E) Results of enzyme-linked immunosorbent assays showing significantly higher amounts of IL-17A secreted by cells isolated from older TxA23 mice compared with younger mice. Each dot represents 1 mouse, 6–18 mice per group.