Table 1.
Clinical and pathological characteristics of patients with estrogen receptor (ER)+ advanced breast cancer according to SNAI2 level
| Cohort 1 | Cohort 2 | |||||||
|---|---|---|---|---|---|---|---|---|
| Parameters | SNAI2 low | SNAI2 high | Number | p a | SNAI2 low | SNAI2 high | Number | p a |
| Age at primary tumor | ||||||||
| ≤ 50 years | 8 | 6 | 14 | 0.86 | 14 | 7 | 21 | 0.11 |
| > 50 years | 43 | 29 | 72 | 20 | 26 | 46 | ||
| Age at metastatic disease | ||||||||
| ≤ 50 years | 3 | 1 | 4 | 0.64 | 7 | 1 | 8 | 0.05 |
| > 50 years | 48 | 34 | 82 | 27 | 32 | 59 | ||
| Size (mm) of primary tumor | ||||||||
| ≤ 20 | 18 | 12 | 30 | 0.24 | 12 | 10 | 22 | 0.34 |
| > 20 to ≤ 50 | 18 | 13 | 31 | 11 | 17 | 28 | ||
| > 50 | 1 | 4 | 5 | 2 | 2 | 4 | ||
| Unknown | 14 | 6 | 20 | 9 | 4 | 13 | ||
| Nodal status of primary tumor Number of positive lymph nodes | ||||||||
| 0 | 11 | 10 | 21 | 0.46 | 7 | 6 | 13 | 0.37 |
| 1–3 | 16 | 10 | 26 | 8 | 10 | 18 | ||
| > 3 | 12 | 11 | 23 | 7 | 11 | 18 | ||
| Unknown | 12 | 4 | 16 | 12 | 6 | 18 | ||
| Grade of primary tumor | ||||||||
| I | 8 | 9 | 17 | 0.06 | 6 | 6 | 12 | 0.06 |
| II | 12 | 15 | 27 | 7 | 16 | 23 | ||
| III | 9 | 2 | 11 | 5 | 1 | 6 | ||
| Unknown | 22 | 9 | 31 | 16 | 10 | 26 | ||
| HER2 status of metastasis | ||||||||
| Normal | 41 | 30 | 71 | 0.62 | 29 | 31 | 60 | 0.11 |
| Amplified | 4 | 1 | 5 | 1 | 2 | 3 | ||
| Unknown | 6 | 4 | 10 | 4 | 0 | 4 | ||
| Dominant site of relapse | ||||||||
| Soft tissue | 38 | 23 | 61 | 0.65 | 15 | 17 | 32 | 0.17 |
| Bone | 8 | 8 | 16 | 15 | 8 | 23 | ||
| Viscera | 5 | 4 | 9 | 4 | 8 | 12 | ||
| Total number | 51 | 35 | 86 | 34 | 33 | 67 | ||
HER2 human epidermal growth factor receptor 2
aχ2 or Fisher’s exact test