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. 2018 Jun 19;16:53. doi: 10.1186/s12951-018-0379-5

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© The Author(s) 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 5 — Effect of TiO₂ exposure in rats on the cecal composition of acetate, propionate, and butyrate after (a) a 7-day treatment (black: control; light green: NM-105 10 mg/kg bw/day; light orange: E171 10 mg/kg bw/day) and (b) a 60-day treatment (black: control; yellow: E171 0.1 mg/kg bw/day; light orange: E171 10 mg/kg bw/day). Points are from individual rats and bars represent the mean. Statistical significance, assessed using GraphPad Prism 4 software, was determined by one-way ANOVA followed by post hoc tests. Significance was set at a p value < 0.05