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. 2018 May 17;14:1744806918781259. doi: 10.1177/1744806918781259

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© The Author(s) 2018

Creative Commons Non Commercial CC BY-NC: This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).

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Figure 6. — The density of VGLUT1-positive terminals was decreased in D2R neurons in CFA group. (A) Double immunostaining for D1R (red, (a) and (c)) and VGLUT1 (green, (a) and (c)), D2R (green, (b) and (d)) and VGLUT1 (red, (b) and (d)). Insets are enlarged image of dashed areas in each figure. Arrowheads indicate VGLUT1-positive terminals contacting with D1R or D2R neurons. Quantitative analysis revealed that the density VGLUT1-positive terminals contacting with D2R neurons was decreased compared with D1R neurons in CFA group (f), and it was unaltered in saline group (e). (B) Double immunostaining for D1R (red, (a) and (c)) and VGLUT2 (orange, (a) and (c)), D2R (green, (b) and (d)) and VGLUT2 (orange, (b) and (d)). Insets are enlarged image of dashed areas in each figure. Arrowheads indicate VGLUT2-positive terminals contacting with D1R or D2R neurons. Quantitative analysis revealed that the density of VGLUT2-positive terminals contacting with D1R and D2R had no significant difference both in saline group (e) and in CFA group (f). Scale bar = 10 µm. The data are presented as the means ± SEM (n = 5/group; *p < 0.05, compared with D1R in CFA group).

VGLUT: vesicular glutamate transporters; CFA: complete Freund’s adjuvant; D1R: dopamine receptor 1; D2R: dopamine receptor 2; SEM: standard error of mean.