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. 2018 Jun 20;12(3):137–149. doi: 10.3727/000000005783992106

Figure 1.

Figure 1

Cotransfections of the RET 5′ flanking region, cloned in a reporter gene vector with expression plasmids for either HOX11L1, HOX11L2, MASH1, PHOX2A, or PHOX2B, induce statistically significant increases of Luciferase activity expressed as folds of activation (p < 0.05) with respect to the empty expression vector (3.1TOPO). Each box represents median values and first and third quartile (error bars) of Luciferase activity. In the left panel, the result of the cotransfection performed in SK-N-MC of HOX11L1 with the RET promoter is reported, while the null effect of the other transcription factors tested in the same cell line on RET promoter is not shown. In the right panel, cotransfections of all the transcription factors with the RET promoter reporter construct are performed in SK-N-BE.