TABLE 1.
GENES DOWNREGULATED DURING STRESS IN WOUND MYELOID CELLS COMPARED TO THE BASELINE SAMPLES
| Probe ID | Gene | Mean | SD |
|---|---|---|---|
| Apoptosis/cell cycle | |||
| 202266_at | TRAF and TNF receptor associated protein | 0.58 | 0.04 |
| 209091_s_at | SH3-domain GRB2-like endophilin B1 | 0.64 | 0.02 |
| 209115_at | ubiquitin-activating enzyme E1C (UBA3 homolog, yeast) | 0.62 | 0.26 |
| 211367_s_at | caspase 1, apoptosis-related cysteine protease (interleukin 1, beta, convertase) | 1.44 | 0.18 |
| 202769_at | cyclin G2 | 1.17 | 0.58 |
| Cell adhesion/motility/growth | |||
| 204774_at | ecotropic viral integration site 2A | 0.62 | 0.10 |
| 211742_s_at | ecotropic viral integration site 2B///ecotropic viral integration site 2B | 1.02 | 0.03 |
| 201012_at | annexin A1 | 1.74 | 0.31 |
| Electron transport | |||
| 200883_at | ubiquinol-cytochrome c reductase core protein II | 1.02 | 0.14 |
| 201599_at | ornithine aminotransferase (gyrate atrophy) | 0.69 | 0.12 |
| 204646_at | dihydropyrimidine dehydrogenase | 0.86 | 0.34 |
| 208638_at | thioredoxin domain containing 7 (protein disulfide isomerase) | 0.50 | 0.24 |
| 209095_at | dihydrolipoamide dehydrogenase (E3 component of pyruvate dehydrogenase complex, 2-oxo-glutarate complex, branched chain keto acid dehydrogenase complex) | 0.88 | 0.12 |
| 213366_x_at | ATP synthase, H+ transporting, mitochondrial F1 complex, gamma polypeptide 1 | 1.06 | 0.58 |
| Fatty acid/carbohydrate metabolism | |||
| 207983_s_at | stromal antigen 2 | 0.76 | 0.10 |
| 209397_at | malic enzyme 2, NAD(+)-dependent, mitochondrial | 2.02 | 0.10 |
| 212689_s_at | jumonji domain containing 1A | 0.69 | 0.06 |
| 217993_s_at | methionine adenosyltransferase II, beta | 0.58 | 0.01 |
| 218250_s_at | CCR4-NOT transcription complex, subunit 7 | 0.64 | 0.14 |
| Golgi/hydrolase | |||
| 204834_at | fibrinogen-like 2 | 0.58 | 0.36 |
| 218241_at | golgi autoantigen, golgin subfamily a, 5 | 0.58 | 0.00 |
| 200975_at | palmitoyl-protein thioesterase 1 (ceroid-lipofuscinosis, neuronal 1, infantile) | 0.52 | 0.14 |
| 201847_at | lipase A, lysosomal acid, cholesterol esterase (Wolman disease) | 0.62 | 0.74 |
| 218277_s_at | DEAH (Asp-Glu-Ala-His) box polypeptide 40 | 0.71 | 0.13 |
| Immune/defense/inflammation | |||
| 200985_s_at | CD59 antigen p18-20 (antigen identified by monoclonal antibodies 16.3A5, EJ16, EJ30, EL32 and G344) | 0.55 | 0.01 |
| 201487_at | cathepsin C | 0.88 | 0.26 |
| 202530_at | mitogen-activated protein kinase 14 | 0.72 | 0.19 |
| 204222_s_at | GLI pathogenesis-related 1 (glioma) | 1.00 | 0.14 |
| 205227_at | interleukin 1 receptor accessory protein | 0.85 | 0.02 |
| 205474_at | cytokine receptor-like factor 3 | 0.77 | 0.16 |
| 208894_at | major histocompatibility complex, class II, DR alpha///major histocompatibility complex, class II, DR alpha | 0.64 | 0.03 |
| 209201_x_at | chemokine (C-X-C motif) receptor 4 | 1.42 | 0.14 |
| 209666_s_at | conserved helix-loop-helix ubiquitous kinase | 0.52 | 0.06 |
| 210982_s_at | major histocompatibility complex, class II, DR alpha | 0.53 | 0.01 |
| 211676_s_at | interferon gamma receptor 1///interferon gamma receptor 1 | 0.92 | 0.18 |
| 211919_s_at | chemokine (C-X-C motif) receptor 4 /// chemokine (C-X-C motif) receptor 4 | 1.44 | 0.14 |
| 211991_s_at | major histocompatibility complex, class II, DP alpha 1 | 0.86 | 0.36 |
| 210176_at | toll-like receptor 1 | 1.88 | 0.04 |
| 200902_at | 15 kDa selenoprotein | 0.71 | 0.12 |
| Nucleic acid binding/metabolism | |||
| 201273_s_at | signal recognition particle 9 kDa | 1.69 | 0.11 |
| 204221_x_at | HIV-1 rev binding protein 2 | 1.12 | 0.20 |
| 206989_s_at | splicing factor, arginine/serine-rich 2, interacting protein | 0.64 | 0.18 |
| 208620_at | poly(rC) binding protein 1 | 0.79 | 0.04 |
| 209786_at | high mobility group nucleosomal binding domain 4 | 1.30 | 0.15 |
| 214085_x_at | HIV-1 rev binding protein 2 | 1.93 | 0.35 |
| 218263_s_at | transposon-derived Buster1 transposase-like protein gene | 1.21 | 0.31 |
| Protein metabolism | |||
| 201398_s_at | translocation associated membrane protein 1 | 0.61 | 0.20 |
| 201745_at | PTK9 protein tyrosine kinase 9 | 0.67 | 0.06 |
| 202413_s_at | ubiquitin specific protease 1 | 0.86 | 0.18 |
| 202653_s_at | axotrophin | 0.52 | 0.13 |
| 202939_at | zinc metalloproteinase (STE24 homolog, yeast) | 0.59 | 0.10 |
| 203403_s_at | ring finger protein (C3H2C3 type) 6 | 1.10 | 0.07 |
| 204759_at | chromosome condensation 1-like | 1.14 | 0.45 |
| 209829_at | chromosome 6 open reading frame 32 | 1.37 | 0.07 |
| 212756_s_at | chromosome 6 open reading frame 133 | 0.59 | 0.01 |
| 212760_at | chromosome 6 open reading frame 133 | 0.61 | 0.10 |
| 217865_at | ring finger protein 130 | 0.67 | 0.12 |
| 217927_at | signal peptidase 12 kDa | 0.77 | 0.16 |
| 218135_at | PTX1 protein | 0.86 | 0.04 |
| 219485_s_at | proteasome (prosome, macropain) 26S subunit, non-ATPase, 10 | 0.98 | 0.40 |
| Receptor activity | |||
| 201312_s_at | SH3 domain binding glutamic acid-rich protein like | 0.67 | 0.14 |
| 202467_s_at | thyroid receptor interacting protein 15 | 0.69 | 0.19 |
| 203799_at | type I transmembrane C-type lectin receptor DCL-1 | 1.64 | 0.27 |
| 209479_at | chromosome 6 open reading frame 80 | 0.69 | 0.22 |
| 220005_at | purinergic receptor P2Y, G-protein coupled, 13///purinergic receptor P2Y, G-protein coupled, 13 | 1.19 | 0.69 |
| Signal transduction/transcription | |||
| 202168_at | TAF9 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 32 kDa | 0.96 | 0.26 |
| 203338_at | protein phosphatase 2, regulatory subunit B (B56), epsilon isoform | 0.66 | 0.06 |
| 204194_at | BTB and CNC homology 1, basic leucine zipper transcription factor 1 | 0.50 | 0.11 |
| 206158_s_at | zinc finger protein 9 (a cellular retroviral nucleic acid binding protein) | 1.04 | 0.08 |
| 209102_s_at | HMG-box transcription factor 1 | 0.71 | 0.10 |
| 212120_at | ras homolog gene family, member Q | 0.58 | 0.07 |
| 212530_at | NIMA (never in mitosis gene a)-related kinase 7 | 0.85 | 0.14 |
| 212536_at | ATPase, Class VI, type 11B | 0.62 | 0.17 |
| 212572_at | serine/threonine kinase 38 like | 0.58 | 0.07 |
| 217873_at | calcium binding protein 39 | 0.81 | 0.10 |
| 221803_s_at | nuclear receptor binding factor 2 | 0.77 | 0.10 |
| 38149_at | Rho GTPase activating protein 25 | 0.94 | 0.35 |
| Transport | |||
| 201078_at | transmembrane 9 superfamily member 2 | 0.67 | 0.14 |
| 202375_at | SEC24 related gene family, member D (S. cerevisiae) | 0.71 | 0.03 |
| 202829_s_at | synaptobrevin-like 1 | 0.64 | 0.05 |
| 208870_x_at | ATP synthase, H+ transporting, mitochondrial F1 complex, gamma polypeptide 1 | 0.58 | 0.55 |
| 209004_s_at | F-box and leucine-rich repeat protein 5 | 0.55 | 0.23 |
| 212192_at | potassium channel tetramerisation domain containing 12 | 2.89 | 0.86 |
| 218304_s_at | oxysterol binding protein-like 11 | 0.56 | 0.01 |
| Miscellaneous | |||
| 200774_at | chromosome 9 open reading frame 10 | 0.69 | 0.16 |
| 203584_at | KIAA0103 | 0.64 | 0.06 |
| 204373_s_at | centrosome-associated protein 350 | 0.55 | 0.04 |
| 209337_at | PC4 and SFRS1 interacting protein 1 | 0.66 | 0.14 |
| 212131_at | chromosome 19 open reading frame 13 | 0.56 | 0.01 |
| 212163_at | likely homolog of rat kinase D-interacting substance of 220 kDa | 0.83 | 0.02 |
| 212179_at | chromosome 6 open reading frame 111 | 0.96 | 0.02 |
| 212267_at | KIAA0261 | 0.62 | 0.16 |
| 212476_at | centaurin, beta 2 | 0.58 | 0.21 |
| 212795_at | KIAA1033 protein | 0.72 | 0.10 |
| 214812_s_at | disco-interacting protein 2 | 0.56 | 0.02 |
| 217766_s_at | small membrane protein 1 | 0.50 | 0.02 |
| 218191_s_at | chromosome 6 open reading frame 209 | 0.72 | 0.02 |
| 218303_x_at | hypothetical protein LOC51315 | 0.55 | 0.03 |
| 219449_s_at | hypothetical protein FLJ20533 | 0.76 | 0.26 |
Data presented indicate fold change (mean ± SD) in gene expression of wound myeloid cells of subjects under stress conditions compared to baseline. Only annotated genes are presented in the list. Probe ID, Affymetrix probe identifications.