TABLE 2.
GENES UPREGULATED DURING STRESS IN WOUND MYELOID CELLS COMPARED TO THE BASELINE SAMPLES
| Probe ID | Gene | Mean | SD |
|---|---|---|---|
| Angiogenesis | |||
| 202509_s_at | tumor necrosis factor, alpha-induced protein 2 | 1.00 | 0.31 |
| 215179_x_at | Placental growth factor, vascular endothelial growth factor-related protein | 0.81 | 0.06 |
| Apoptosis/ cell cycle arrest | |||
| 200797_s_at | myeloid cell leukemia sequence 1 (BCL2-related) | 0.59 | 0.03 |
| 201502_s_at | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | 0.52 | 0.06 |
| 221780_s_at | DEAD (Asp-Glu-Ala-Asp) box polypeptide 27 | 0.86 | 0.03 |
| 215628_x_at | protein phosphatase 2 (formerly 2A), catalytic subunit, alpha isoform | 0.79 | 0.01 |
| Cell adhesion | |||
| 202877_s_at | complement component 1, q subcomponent | 1.56 | 0.21 |
| Cell cycle/growth & motility | |||
| 208900_s_at | topoisomerase (DNA) I | 0.77 | 0.09 |
| 40225_at | cyclin G associated kinase | 0.59 | 0.00 |
| 215889_at | SKI-like | 0.98 | 0.10 |
| 201668_x_at | myristoylated alanine-rich protein kinase C substrate | 1.17 | 0.17 |
| 202205_at | vasodilator-stimulated phosphoprotein | 0.69 | 0.08 |
| Glutathione metabolism | |||
| 207131_x_at | gamma-glutamyltransferase 1 | 0.94 | 0.14 |
| 208284_x_at | gamma-glutamyltransferase 1 | 0.81 | 0.23 |
| 209919_x_at | gamma-glutamyltransferase 1 | 0.86 | 0.05 |
| 211416_x_at | gamma-glutamyltransferase-like activity 4 | 0.59 | 0.05 |
| 211417_x_at | gamma-glutamyltransferase 1 | 0.98 | 0.19 |
| Immune/stress/defense response | |||
| 204158_s_at | T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 protein a isoform 3 | 0.58 | 0.07 |
| 205483_s_at | interferon, alpha-inducible protein (clone IFI-15K) | 1.04 | 0.19 |
| 212659_s_at | interleukin 1 receptor antagonist | 1.59 | 0.40 |
| 208436_s_at | interferon regulatory factor 7 | 1.02 | 0.44 |
| 201680_x_at | arsenate resistance protein ARS2 | 0.74 | 0.12 |
| 215067_x_at | peroxiredoxin 2 | 1.06 | 0.04 |
| 222047_s_at | arsenate resistance protein ARS2 | 0.77 | 0.06 |
| Metabolism | |||
| 201818_at | hypothetical protein FLJ12443 | 0.98 | 0.15 |
| 205370_x_at | dihydrolipoamide branched chain transacylase (E2 component of branched chain keto acid dehydrogenase complex; maple syrup urine disease) | 0.62 | 0.10 |
| Nucleic acid metabolism | |||
| 213593_s_at | transformer-2 alpha | 0.90 | 0.07 |
| 218695_at | exosome component 4 | 1.21 | 0.08 |
| 58696_at | exosome component 4 | 0.90 | 0.03 |
| 91684_g_at | exosome component 4 | 0.90 | 0.10 |
| 208246_x_at | thymidine kinase 2, mitochondrial | 0.88 | 0.10 |
| Protein metabolism | |||
| 215600_x_at | F-box and WD-40 domain protein 12 | 1.42 | 0.00 |
| 201933_at | procollagen (type III) N-endopeptidase | 0.52 | 0.06 |
| Signal transduction/transcription | |||
| 201693_s_at | early growth response 1 | 1.51 | 0.19 |
| 202426_s_at | retinoid X receptor, alpha | 0.56 | 0.08 |
| 206792_x_at | phosphodiesterase 4C, cAMP-specific (phosphodiesterase E1 dunce homolog, Drosophila) | 0.74 | 0.08 |
| 209050_s_at | ral guanine nucleotide dissociation stimulator | 1.93 | 0.41 |
| 209695_at | protein tyrosine phosphatase type IVA, member 3 | 0.69 | 0.04 |
| 213812_s_at | calcium/calmodulin-dependent protein kinase kinase 2, beta | 0.58 | .11 |
| 215404_x_at | fibroblast growth factor receptor 1 (fms-related tyrosine kinase 2, Pfeiffer syndrome) | 0.71 | 0.11 |
| 209912_s_at | forkhead box K1 | 1.08 | 0.04 |
| 214715_x_at | zinc finger protein 160 | 1.14 | 0.04 |
| Transport | |||
| 202856_s_at | solute carrier family 16 (monocarboxylic acid transporters), member 3 | 0.69 | 0.10 |
| 202807_s_at | target of myb1 (chicken) | 0.64 | 0.07 |
| 214594_x_at | ATPase, Class I, type 8B, member 1 | 1.17 | 0.03 |
| 219952_s_at | mucolipin 1 | 1.23 | 0.46 |
| 220796_x_at | solute carrier family 35, member E1 | 0.71 | 0.04 |
| 50277_at | golgi associated, gamma adaptin ear containing, ARF binding protein 1 | 1.02 | 0.08 |
| Miscellaneous | |||
| 203718_at | neuropathy target esterase | 1.32 | 0.10 |
| 206548_at | hypothetical protein FLJ23556 | 1.32 | 0.05 |
| 208112_x_at | EH-domain containing 1 | 0.61 | 0.04 |
| 208610_s_at | serine/arginine repetitive matrix 2 | 1.25 | 0.04 |
| 209039_x_at | EH-domain containing 1 | 0.77 | 0.08 |
| 213300_at | KIAA0404 protein | 0.59 | 0.03 |
| 214657_s_at | trophoblast-derived noncoding RNA | 1.37 | 0.22 |
| 214902_x_at | FLJ42393 protein | 0.92 | 0.04 |
| 215553_x_at | WD repeat domain 45 | 0.66 | 0.11 |
| 218155_x_at | hypothetical protein FLJ10534 | 0.92 | 0.05 |
| 219392_x_at | hypothetical protein FLJ11029 | 1.17 | 0.35 |
| 220071_x_at | chromosome 15 open reading frame 25 | 0.74 | 0.16 |
| 221495_s_at | KIAA1049 protein | 0.62 | 0.02 |
| 221704_s_at | hypothetical protein FLJ12750///hypothetical protein FLJ12750 | 1.10 | 0.02 |
| 221867_at | Nedd4 binding protein 1 | 1.02 | 0.35 |
| 41386_i_at | jumonji domain containing 3 | 1.37 | 0.14 |
| 41387_r_at | jumonji domain containing 3 | 1.00 | 0.13 |
| 54970_at | hypothetical protein DKFZp761I2123 | 1.10 | 0.10 |
| 215529_x_at | chromosome 21 open reading frame 106 | 0.69 | 0.12 |
Data presented indicate fold change (mean ± SD) in gene expression of wound myeloid cells of subjects under stress conditions compared to baseline. Only annotated genes are presented in the list. Probe ID, Affymetrix probe identifications.