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Mesenchymal stem cells but not skin fibroblasts harbor osteogenic differentiation abilities. Mesenchymal stem cells without induction of osteogenesis show no expression of alkaline phosphatase (LAP) by FACS analysis or calcium deposits in von Kossa staining (A). After induction of bone differentiation elevated LAP levels and a significant amount of calcium deposits can be detected in former mesenchymal stem cells (B), but not in skin fibroblasts (C).
