TABLE 2.
GENES THAT WERE FOUND TO BE UPREGULATED AND DOWNREGULATED IN MSC VERSUS SKIN FIBROBLASTS
| Expression Level | Accession Number | Gene Name | Function (References) |
|---|---|---|---|
| Upregulated genes | |||
| 10.0 | AA430540 | Collagen, type IV, alpha 2 | extracellular matrix protein |
| 8.8 | N74623 | Insulin-like growth factor-2 | regulation of normal cell growth (59) |
| 7.2 | AA136707 | Procollagene-lysine, 2-oxoglutarate 5-dioxygenase | collagen synthesis |
| 6.0 | AA459308 | Elastin | protein that provides the property of elastic recoil in dermis, lungs, and blood vessels (67) |
| 5.6 | N74882 | Distal-less homeobox 5 | organ development, limb initiation (21,95) |
| 5.4 | AA460975 | Scrapie responsive protein 1 | expressed by cells of neural origin in mouse embryo (15) |
| 4.6 | AA482119 | Inhibitor of DNA binding 3 | plays a role in keeping precursor cells immature (94) |
| 4.5 | T52830 | Human insulin-like growth factor binding protein 5 | growth and differentiation (26,53) |
| 4.4 | AA421819 | Cadherin 6, type 2, K-cadherin | cell adhesion molecule, expressed in normal kidney and renal cell carcinoma (65) |
| 4.0 | W49619 | Cadherin 2, type 1, N-cadherin | neural development (46,47) |
| 4.0 | AA487193 | Secreted frizzled-related protein 4 | transmembrane receptor; WNT network (19,34) |
| 4.0 | W72803 | EGF-TM7 latrophilin-related protein | transmembrane receptor, neutrophil migration (41) |
| 3.7 | R76614 | Netrin 4 | neuronal development (2,35,93) |
| 3.7 | AA074535 | Hematopoetic PBX-interacting protein | organization of cytoskeleton (1) |
| 3.4 | R92455 | LIM protein | angiogenesis and hematopoiesis (90,91) |
| 3.4 | AA402754 | Eyes absent (Drosophila) homolog 2 | dynamic expression during development (17) |
| 3.4 | H79023 | Disintegrin and metalloproteinase (meltrin α) ADAM 12 | disintegrin and metalloproteinase is expressed in human and rat brain, developing and regenerating heart, and skeletal muscle (7) |
| 3.3 | R55185 | EST, highly similar to IRX3 mouse II | IRX3 is involved in WNT signaling in developing neural tissue (9) and developing heart (12) |
| 3.3 | AA417279 | Protein tyrosine phosphatase, non-receptor type substrate 1 | expressed in rat kidney (55) |
| 3.1 | N79778 | Extracellular matrix protein 2 | extracellular matrix protein, female organ and adipocyte specific |
| 3.1 | R82176 | MAD (mothers against dpp = decapen-taplegic) homolog 7 | embryonic midgut development in drosophila; BMP-4 signaling pathway (58) |
| Downregulated genes | |||
| −30.3 | N32768 | Pregnancy specific beta-1-glycoprotein 3 | immunomodulating function (80) |
| −25.0 | W48852 | Cysteine knot superfamily 1 | growth factors (52) |
| −10.6 | R48303 | Dermatopontin | proteoglycan-binding cell adhesion protein, interacts with TGF-β (64) |
| −10.5 | AA496334 | Dynamin 1 | endocytosis (11) |
| −10.0 | AA430540 | Collagen, type IV, alpha 2 | extracellular matrix protein |
| −9.3 | AA148548 | Fatty acid binding protein 3 | fatty acid metabolism, trafficking, and signaling (71) |
| −8.7 | AA644088 | Cathepsin C | activates serin proteases like progranzymes (83,88) |
| −8.1 | N50845 | Contactin 3 | adhesion molecule, neural development (62,63) |
| −7.0 | H09748 | B-cell CLL/lymphoma 11B | zinc finger protein |
| −6.8 | T50121 | Kreisler maf-related leucine zipper homolog | transcription factor, activated HOXb-3 in segmental regulation (48) |
| −6.8 | W49781 | Leupaxin | phosphotyrosine protein most homologous to paxillin preferentially expressed in hematopoietic cells (45) |
| −6.3 | R66101 | Neuritin | neurogenesis (57) |
| −5.8 | W35153 | G protein-coupled receptor, family C, group 5, member B | |
| −5.7 | AA425947 | Dickkopf (Xenopus laevis) homolog 3 | candidate tumor suppressor gene (37,61) |
| −4.0 | N89673 | Peroxisome proliferative activated receptor γ coactivator 1 | fat metabolism, transcriptional coactivator (18,38) |
| −3.8 | AA490462 | AE-binding protein 1 | regulated in adipogenesis and vascular smooth muscle cell differentiation (74) |
| −3.6 | AA071473 | Matrilin 2 | development of cartilage and bones (23) |
| −3.6 | R09561 | Decay accelerating factor for complement | membrane-bound complement-regulatory protein (CD55, Cromer blood group system) (81) |
| −3.5 | N79484 | Extracellular matrix protein 1 | bone development and angiogenesis (33,54) |
| −3.4 | N23996 | SWAP-70 protein | Signaling of membrane ruffling (78) |
| −3.3 | N98485 | Forkhead box F2 | Potential transcriptional factor |
| −3.2 | H19315 | Contactin 1 | neural cell adhesion molecule |