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. 2018 May 28;14:1215–1221. doi: 10.3762/bjoc.14.103

Scheme 5.

Scheme 5

Reaction of alkynylbenziodoxole derivatives for acyl radical alkynylation in photoredox catalysis. Reaction conditions: a) ketoacid 8 (0.15 mmol, 1.5 equiv), alkynylbenziodoxole 3 (0.10 mmol, 1.0 equiv), Ru(bpy)3(PF6)2 (0.002 mmol, 0.02 equiv), and BIOAc (0.10 mmol, 1.0 equiv) in 2.0 mL DCM for 5 h under a nitrogen atmosphere; b) β-ketone alcohol 10 (0.20 mmol, 2.0 equiv), alkynylbenziodoxole 3 (0.10 mmol, 1.0 equiv), Ru(bpy)3(PF6)2 (0.002 mmol, 0.02 equiv), and BI-OAc (0.20 mmol, 2.0 equiv) in 2.0 mL DCM for 24 h under a nitrogen atmosphere. Yields are isolated yields.