Table 1.
Cytotoxicity of cryptophycin-52 and its unit B analogues.
| compd | unit B | IC50 KB-3-1 (nM) |
| 2 | CH2Ph(m-Cl,p-OMe) | 0.015 |
| 22 | CH2Ph(m-Cl,p-(OCH2CH2)3N3) | 195000 |
| 23 | CH2Ph(m-Cl,p-OCH2CH2OCH2CHCH2) | 0.748 |
| 24 | CH2Ph(m-Cl,p-OCH2CH2OH) | 0.184 |
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