Table 10.
The solid-supported CuSAC reaction in batch or flow reactor.
 | |||||
| entry | R1 | R3 | solvent | reaction (residence) time | yield [%] |
| 1 | Ph | Ph |
o-DCB toluene |
2 h (5 min) |
100 100 |
| 2 | Ph | COOEt |
o-DCB toluene |
6 h (5 min) |
71 95 |
| 3 | Ph | cyclopentyl |
o-DCB toluene |
6 h (15 min) |
33 73 |
| 4 | Ph | CH2OH |
o-DCB toluene |
20 h (15 min) |
69 18 |
| 5 | Ph | 2-Py |
o-DCB toluene |
7 h (5 min) |
70 24 |
| 6 | 4-MeO-Ph | Ph |
o-DCB toluene |
5 h (5 min) |
85 75 |
| 7 | 4-MeO-Ph | COOEt |
o-DCB toluene |
6 h (5 min) |
47 56 |
| 8 | 4-MeO-Ph | cyclopentyl |
o-DCB toluene |
6 h (15 min) |
28 24 |
| 9 | 4-MeO-Ph | CH2OH |
o-DCB toluene |
20 h (15 min) |
55 33 |
| 10 | 4-MeO-Ph | 2-Py |
o-DCB toluene |
7.5 h (10 min) |
68 26 |
| 11 | Bn | Ph |
o-DCB toluene |
16 h (5 min) |
47 77 |
| 12 | Bn | COOEt | o-DCB | 16 h | 21 |