Table 2. . Progression-free survival according to histopathological diagnosis and molecular classes and by linking histology and molecular classes.
| Parameter/factor | Median (months) | 2 years % (95% CI) | 3 years % (95% CI) | 5 years % (95% CI) |
|---|---|---|---|---|
| Histology | ||||
| AO | 32.5 | 70.7 (56.0–81.3) | 39.3 (22.2–56) | 39.3 (22.2–56) |
| AOA | 24.4 | 58.3 (40.7–72.4) | 36.5 (19.9–53.3) | 36.5 (19.9–53.3) |
| AA | 27.1 | 63.6 (45.0–77.5) | 0 | 0 |
| Molecular classes | ||||
| Class I | 30.4 | 72.7 (60.0–81.9) | 49.3 (33.7–63.2) | 49.3 (33.7–63.2) |
| Class II | 27.1 | 69.2 (52.2–81.2) | 0 | 0 |
| Class III | 9.9 | 20.0 (4.9–42.4) | 0 | 0 |
| Histology and molecular classes linked | ||||
| AO IDH-mutated/1p19q co-codeleted | Not reached | 73.1 (57.3–84.0) | 51.2 (32.6–67.1) | 51.2 (32.6–67.1) |
| AO IDH-mutated/1p19q no-codeleted | 9.9 | 50.0 (11.1–80.4) | 0 | 0 |
| AOA IDH-mutated/1p19q codeleted | 77.0 | 60.0 (31.8–79.7) | 60.0 (31.8–79.7) | 60 (31.8–79.7) |
| AOA IDH-mutated/1p19q no-codeleted | 27.1 | 80.0 (50.0–93.1) | 0 | 0 |
| AOA IDH-wild-type | 9.8 | 0 | 0 | 0 |
| AA IDH-mutated/1p19q codeleted | 27.1 | 100.0 | 0 | 0 |
| AA IDH-mutated/1p19q no-codeleted | 25.9 | 66.6 (40.4–83.4) | 0 | 0 |
| AA IDH-wild-type | 8.7 | 3.3 (7.8–62.3) | 0 | 0 |
AA: Anaplastic astrocytoma; AO: Anaplastic oligodendroglioma; AOA: Anaplastic oligoastrocytoma; Class I: IDH-mutated/1p19q codeleted tumor; Class II: IDH-mutated/1p19q no-codeleted tumor; Class III: IDH-wild-type tumor.