Table 3. . Overall Survival according to histopathological diagnosis and molecular classes and by linking histology and molecular classes.
| Parameter/factor | Median (months) | 2 years % (95% CI) | 3 years % (95% CI) | 5 years % (95% CI) |
|---|---|---|---|---|
| Histology | ||||
| AO | Not reached | 93.3 (56.0–81.3) | 93.3 (80.7–97.8) | 80.0 (59.1–91.0) |
| AOA | 40.5 | 82.5 (65.1–91.8) | 82.5 (65.1–91.8) | 49.5 (26.8–68.7) |
| AA | 46 | 90.9 (74.4–97) | 70.7 (51.2–83.6) | 47.1 (27.9–64.2) |
| Molecular classes | ||||
| Class I | Not reached | 94.7 (84.6–98.3) | 94.7 (84.6–98.3) | 56.8 (35.1–73.7) |
| Class II | Not reached | 92.3 (52.2–81.2) | 75.5 (58.2–86.5) | 62.9 (43.1–77.5) |
| Class III | 40.5 | 60.0 (31.8–79.7) | 60.0 (31.8–79.7) | 40.0 (16.5–62.8) |
| Histology and molecular classes linked | ||||
| AO IDH-mutated/1p19q co-codeleted | Not reached | 92.3 (78.0–97.5) | 92.3 (78.0–97.5) | 61.0 (42.0–71.0) |
| AO IDH-mutated/1p19q no-codeleted | Not reached | 100.0 | 100.0 | 55.0 (31.0–67.0) |
| AOA IDH-mutated/1p19q codeleted | 39.2 | 100.0 | 100.0 | 50.0 (11.1–80.4) |
| AOA IDH-mutated/1p19q no-codeleted | 23.2 | 80.0 (50.0–93.1) | 80.0 (50.0–93.1) | 0 |
| AOA IDH-wild-type | 18.7 | 50.0 (11.1–80.4) | 50.0 (11.1–80.4) | 0 |
| AA IDH-mutated/1p19q codeleted | 45.9 | 100.0 | 100.0 | 0 |
| AA IDH-mutated/1p19q no-codeleted | 43.5 | 100.0 | 66.7 (40.4–83.4) | 0 |
| AA IDH-wild-type | 9.3 | 66.7 (28.2–87.8) | 66.7 (28.2–87.8) | 66.7 (28.2–87.8) |
AA: Anaplastic astrocytoma; AO: Anaplastic oligodendroglioma; AOA: Anaplastic oligoastrocytoma; Class I: IDH-mutated/1p19q codeleted tumor; Class II: IDH-mutated/1p19q no-codeleted tumor; Class III: IDH-wild-type tumor.