Table 1.

Schedule of enrolment, interventions and assessments

Age (months)	2	3	4	5	6	7	9	9.5	10	12	18	19	24
Enrolment
Informed consent	X										X*
Eligibility assessment	X										X*
Allocation	X
Interventions
PCV10—group A	X	X	X				X
PCV10—group B	X	X	X
PCV10—group C	X		X					X
PCV10—group D	X				X
PCV13—group E	X		X					X
PCV10—group F											X		X
PCV10—group G													X
Assessments
Demographics	X										X*
Household characteristics	X										X*
Nasopharyngeal swab	X				X		X			X	X		X
Blood sample—group A	X†			X			X		X		X†
Blood sample—group B				X	X		X†		X		X†
Blood sample—group C				X	X†		X		X		X†
Blood sample—group D		X			X	X	X†				X†
Blood sample—group E		X†		X			X		X		X†
Blood sample—group F											X	X	X
Blood sample—group G											X	X	X
General health	X	X	X	X	X	X	X	X	X	X	X	X	X

*Group G only. Any events occurring before 18 months do not apply to group G.

†Each participant provides only one of these blood samples (the last 50 participants per group enrolled into groups A–E provide this blood sample at 18 months; the remainder provide it at the other time point).