Fig. 7. Biomedical applications of the multifunctional nanosystem for selective cancer cell recognition, intracellular bioimaging, and targeted anticancer drug delivery. Flow cytometry results of (a) target CEM cells and (b) nontarget Ramos cells. (c) Confocal microscopy images showing that the sgc8-modified nanosystem was internalized into target CEM cells after incubation at 37 °C for 4 h, and the fluorescence of UCNPs was recovered. T₁-Weighted MRI images of (d) CEM cells and (e) Ramos cells treated with the sgc8-nanosystem at concentrations of 0, 25, and 50 μg mL^–1. Cytotoxicity of the Dox-loaded sgc8-nanosystem (sgc8-NS-Dox) and the lib-nanosystem (lib-NS-Dox) in (f) CEM cells and (g) Ramos cells, in contrast to nonselective toxicity of free Dox in both cell lines.