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. 2018 Mar 21;46(11):5809–5821. doi: 10.1093/nar/gky214

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© The Author(s) 2018. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Figure 4. — Knockdown of OCC-1 increased the expression of genes involved in cell growth in Caco-2 cells. (A) Venn diagram showing that the differentially expressed genes (DEGs) of these two OCC-1 shRNAs identified by microarray were largely overlapped. (B) A heat-map showing the 592 DEGs in Caco-2 cells, with most of the DEGs (93%, 554) were upregulated upon OCC-1 knockdown. (C) Gene ontology (GO) enrichment analysis of the 521 GO annotated OCC-1-repressed genes revealed that OCC-1 mainly represses the expression of post-transcriptional and translational regulators in gene expression. (D) RT-qPCR validation of the expression changes of several OCC-1-repressed genes that have been implicated in cancer cell growth. Data are presented as mean± standard deviation of three independent experiments. **P < 0.01.