Table 1. (A and B) Transcription factors (TFs) exhibiting similar genomic distributions to that of LSD1. LSD1 peaks were divided into two groups, LSD1-bound promoters (<TSS ± 1 kb) (A) and outside of promoters (>TSS ± 1 kb) (B). An extensive comparison with publicly available datasets was conducted for each group, using the ChIP-Atlas (http://chip-atlas.org/). Top 10 rankings are shown.
Rank | ID | Antigen | Cell | Num of peaks | Overlaps / LSD1 | Overlaps / random | Fold enrichment | P-value | Q-value |
---|---|---|---|---|---|---|---|---|---|
(A) TFs similarly distributed with LSD1 (<TSS ± 1 kb) | |||||||||
1 | SRX3206550 | Brd4 | Muscle, Skeletal | 5236 | 4424/11268 | 27/11268 | 163.852 | <1.0 × 10−324 | <1.0 × 10−324 |
2 | SRX3206547 | Brd4 | Muscle, Skeletal | 6926 | 5690/11268 | 39/11268 | 145.897 | <1.0 × 10−324 | <1.0 × 10−324 |
3 | SRX3206545 | Brd4 | Muscle, Skeletal | 9561 | 7152/11268 | 50/11268 | 143.04 | <1.0 × 10−324 | <1.0 × 10−324 |
4 | SRX142538 | E2f4 | C2C12 | 2379 | 1628/11268 | 13/11268 | 125.231 | <1.0 × 10−324 | <1.0 × 10−324 |
5 | SRX522661 | Sin3a | C2C12 | 2230 | 1845/11268 | 15/11268 | 123 | <1.0 × 10−324 | <1.0 × 10−324 |
6 | SRX956815 | Six4 | C2C12 | 4850 | 3510/11268 | 29/11268 | 121.034 | <1.0 × 10−324 | <1.0 × 10−324 |
7 | SRX344972 | Sin3a | C2C12 | 1797 | 1405/11268 | 12/11268 | 117.083 | <1.0 × 10−324 | <1.0 × 10−324 |
8 | SRX150192 | Hdac1 | Myoblasts | 2823 | 1217/11268 | 11/11268 | 110.636 | <1.0 × 10−324 | <1.0 × 10−324 |
9 | SRX142525 | Max | C2C12 | 6364 | 2661/11268 | 30/11268 | 88.7 | <1.0 × 10−324 | <1.0 × 10−324 |
10 | SRX142526 | Rest | C2C12 | 5494 | 1466/11268 | 17/11268 | 86.2353 | <1.0 × 10−324 | <1.0 × 10−324 |
(B) TFs similarly distributed with LSD1 (>TSS ± 1 kb) | |||||||||
1 | SRX770038 | Myod1 | C2C12 | 4298 | 3786/40746 | 60/40746 | 63.1 | <1.0 × 10−324 | <1.0 × 10−324 |
2 | SRX142533 | Fosl1 | C2C12 | 3696 | 2664/40746 | 45/40746 | 59.2 | <1.0 × 10−324 | <1.0 × 10−324 |
3 | SRX328690 | Myod1 | C2C12 | 10980 | 8705/40746 | 153/40746 | 56.8954 | <1.0 × 10−324 | <1.0 × 10−324 |
4 | SRX142529 | Tcf12 | C2C12 | 7817 | 6126/40746 | 112/40746 | 54.6964 | <1.0 × 10−324 | <1.0 × 10−324 |
5 | SRX142537 | Myod1 | C2C12 | 12521 | 8722/40746 | 166/40746 | 52.5422 | <1.0 × 10−324 | <1.0 × 10−324 |
6 | SRX142515 | Myog | C2C12 | 5718 | 4341/40746 | 84/40746 | 51.6786 | <1.0 × 10−324 | <1.0 × 10−324 |
7 | SRX142516 | Myod1 | C2C12 | 3446 | 2568/40746 | 50/40746 | 51.36 | <1.0 × 10−324 | <1.0 × 10−324 |
8 | SRX1817465 | Tead4 | C2C12 | 1697 | 1478/40746 | 29/40746 | 50.9655 | <1.0 × 10−324 | <1.0 × 10−324 |
9 | SRX039346 | Epitope tags | C2C12 | 3133 | 1462/40746 | 29/40746 | 50.4138 | <1.0 × 10−324 | <1.0 × 10−324 |
10 | SRX213538 | Mef2d | C2C12 | 3551 | 1840/40746 | 37/40746 | 49.7297 | <1.0 × 10−324 | <1.0 × 10−324 |