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. 2018 Jan 12;5(4):499–522. doi: 10.1016/j.jcmgh.2018.01.006

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© 2018 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

PMC Copyright notice

Bile acid metabolism and small intestinal morphologic changes in adult male WT, Asbt^-/-, Ostα^-/-, and Asbt^-/-Ostα^-/-mice. (A) Fecal bile acid excretion. (B) Ileal expression of Asbt and FGF15 mRNA. (C) Hepatic expression of Cyp7a1 and Cyp8b1 in adult male mice for the indicated genotypes. The mRNA expression (n = 5) was determined by real-time PCR analysis (in triplicate) and normalized using cyclophilin. The mRNA expression is expressed relative to WT (set at 100%). Male mice (age, 8 wk) were included in the analysis (n = 5 per genotype). Mean values ± SEM are shown. Different lowercase letters indicate significant differences (P < .05) between genotypes. BW, body weight.