Table 2.
Characteristics of cohort of biopsy-proven NASH patients
| Steatosis 0–1 | Steatosis 2–3 | p (T-test) | |
|---|---|---|---|
| n | 40 | 36 | / |
| M/F | 22/18 | 24/12 | NS (Chi-Squared) |
| Age (years) | 58.5 ± 1.7 | 53.6 ± 1.9 | NS (0.06) |
| BMI (kg/m2) | 31.6 ± 0.6 | 32.6 ± 0.9 | NS |
| Metabolic assessment | |||
| Glucose (mmol/L) | 6.2 ± 0.3 | 7.0 ± 0.4 | NS (0.1) |
| Insulin (pmol/L) | 109.6 ± 11.0 | 130.7 ± 12.6 | NS |
| HOMA2-IR | 2.1 ± 0.2 | 2.5 ± 0.2 | NS |
| TAGs (mmol/L) | 1.8 ± 0.2 | 1.9 ± 0.3 | NS |
| Total cholesterol (mmol/L) | 4.3 ± 0.2 | 4.3 ± 0.1 | NS |
| LDL cholesterol (mmol/L) | 2.6 ± 0.2 | 2.6 ± 0.1 | NS |
| HDL cholesterol (mmol/L) | 1.0 ± 0.1 | 1.0 ± 0.03 | NS |
| Liver function tests | |||
| AST (U/L) | 41.5 ± 3.8 | 46.7 ± 3.9 | NS |
| ALT (U/L) | 53.02 ± 3.9 | 72.9 ± 6.3 | < 0.01* |
| ALP (U/L) | 118.4 ± 9.5 | 104.1 ± 6.7 | NS |
| Histology | |||
| NASH activity score | 2.8 ± 0.2 | 4.8 ± 0.2 | < 0.01* |
| - Steatosis | 0.8 ± 0.02 | 2.3 ± 0.1 | < 0.01* |
| - Ballooning | 0.7 ± 0.1 | 1.0 ± 0.1 | 0.03* |
| - Inflammation | 1.4 ± 0.1 | 1.5 ± 0.1 | NS |
| Fibrosis | 1.5 ± 0.2 | 1.8 ± 0.2 | NS |
* p < 0.05