Table 2 (online).
Univariate analysis for association of baseline ocular and fundus characteristics with visual acuity outcomes at 5 years
| # of subjects at 5 years (N=647) | VA score (letters) at 5 years | Change in VA score (letters) from baseline at 5 years | ≥ 3-line gain from baseline at 5 years | VA 20/200 or worse at 5 years | |||||
|---|---|---|---|---|---|---|---|---|---|
|
| |||||||||
| Baseline Ocular Characteristics | n | Mean (SE) | P-value§ | Mean (SE) | P-value§ | n (%) | P-value┼ | n (%) | P-value┼ |
| Baseline VA in study eye | <0.001 (<0.001) | 0.005 (<0.001) | <0.001 (<0.001) | <0.001 (<0.001) | |||||
| 20/25 – 20/40 | 268 | 67.7 (1.2) | −6.4 (1.2) | 6 (2.2%) | 27 (10.1%) | ||||
| 20/50 – 20/80 | 231 | 58.1 (1.5) | −2.8 (1.5) | 57 (24.7%) | 42 (18.2%) | ||||
| 20/100–20/160 | 110 | 47.3 (2.3) | 0.8 (2.3) | 40 (36.4%) | 41 (37.3%) | ||||
| 20/200–20/320 | 38 | 35.5 (3.7) | 3.6 (3.7) | 11 (28.9%) | 19 (50.0%) | ||||
| Baseline VA in fellow eye | 0.07 (0.02) | 0.23 (0.10) | 0.82 (0.56) | 0.29 (0.17) | |||||
| 20/20 or better | 229 | 61.6 (1.6) | −2.0 (1.4) | 42 (18.3%) | 38 (16.6%) | ||||
| 20/25–20/40 | 249 | 58.3 (1.6) | −2.9 (1.5) | 45 (18.1%) | 54 (21.7%) | ||||
| 20/50 or worse | 169 | 56.1 (1.8) | −5.7 (1.7) | 27 (16.0%) | 37 (21.9%) | ||||
| Baseline area of CNV (disc area) | 0.02 (0.002) | 0.01 (0.001) | 0.27 (0.14) | 0.10 (0.02) | |||||
| ≤1 | 277 | 63.0 (1.3) | −0.0 (1.2) | 56 (20.2%) | 42 (15.2%) | ||||
| >1 to ≤2 | 127 | 58.7 (2.2) | −3.6 (1.9) | 20 (15.7%) | 25 (19.7%) | ||||
| >2 to ≤4 | 116 | 57.3 (2.4) | −5.0 (2.4) | 22 (19.0%) | 24 (20.7%) | ||||
| >4 | 52 | 54.0 (3.7) | −9.9 (3.2) | 5 (9.6%) | 15 (28.8%) | ||||
| Baseline total area of CNV lesion (disc area) | <0.001 (<0.001) | 0.01 (0.001) | 0.10 (0.28) | 0.003 (<0.001) | |||||
| ≤1 | 222 | 63.5 (1.4) | −0.7 (1.3) | 39 (17.6%) | 32 (14.4%) | ||||
| >1 to ≤2 | 146 | 60.3 (1.9) | −1.7 (1.9) | 29 (19.9%) | 26 (17.8%) | ||||
| >2 to ≤4 | 148 | 56.2 (2.1) | −5.0 (2.1) | 31 (20.9%) | 34 (23.0%) | ||||
| >4 | 109 | 51.0 (2.6) | −8.7 (2.2) | 11 (10.1%) | 34 (31.2%) | ||||
| Location of lesion | 0.02 | 0.75 | 0.03 | 0.04 | |||||
| Not Subfoveal | 170 | 62.7 (1.6) | −2.8 (1.6) | 21 (12.4%) | 25 (14.7%) | ||||
| Subfoveal | 469 | 57.5 (1.2) | −3.4 (1.1) | 92 (19.6%) | 103 (22.0%) | ||||
| Lesion type | 0.11 | 0.10 | <0.001 | 0.053 | |||||
| Occult only | 392 | 60.1 (1.2) | −4.5 (1.1) | 50 (12.8%) | 69 (17.6%) | ||||
| Predominantly or Minimally classic | 242 | 56.9 (1.6) | −1.5 (1.5) | 62 (25.6%) | 58 (24.0%) | ||||
| RAP lesion | 0.51 | 0.21 | 0.16 | 0.74 | |||||
| No | 575 | 58.6 (1.0) | −3.6 (0.9) | 98 (17.0%) | 117 (20.3%) | ||||
| Yes | 62 | 60.7 (3.0) | 0.1 (2.9) | 15 (24.2%) | 11 (17.7%) | ||||
| Blocked fluorescence lesion | 0.39 | 0.10 | 0.08 | 0.57 | |||||
| No | 547 | 58.6 (1.0) | −3.8 (1.0) | 91 (16.6%) | 112 (20.5%) | ||||
| Yes | 93 | 60.9 (2.4) | 0.3 (2.2) | 23 (24.7%) | 16 (17.2%) | ||||
| Fibrotic or atrophic scar | 0.03 | 0.84 | 0.07 | 0.26 | |||||
| No | 620 | 59.3 (1.0) | −3.2 (0.9) | 107 (17.3%) | 122 (19.7%) | ||||
| Yes | 20 | 47.4 (6.0) | −4.3 (6.2) | 7 (35.0%) | 6 (30.0%) | ||||
| Hemorrhage associated with the lesion | 0.006 (0.004) | 0.26 (0.57) | <0.001 (0.01) | 0.02 (0.01) | |||||
| None | 249 | 61.2 (1.4) | −4.6 (1.4) | 27 (10.8%) | 42 (16.9%) | ||||
| ≤1 disc area | 330 | 58.7 (1.4) | −1.9 (1.3) | 77 (23.3%) | 66 (20.0%) | ||||
| >1 disc area | 60 | 50.2 (3.3) | −5.4 (2.7) | 9 (15.0%) | 20 (33.3%) | ||||
| Geographic atrophy | 0.13 | 0.81 | 0.55 | 0.57 | |||||
| None | 600 | 59.3 (1.0) | −3.3 (0.9) | 104 (17.3%) | 118 (19.7%) | ||||
| Present | 47 | 53.7 (3.6) | −4.1 (3.3) | 10 (21.3%) | 11 (23.4%) | ||||
| Intraocular pressure (mmHg) | 0.15 (0.06) | 0.65 (0.44) | 0.61 (0.34) | 0.58 (0.45) | |||||
| <10 | 10 | 62.9 (6.6) | −3.8 (6.8) | 2 (20.0%) | 2 (20.0%) | ||||
| 10–20 | 602 | 59.3 (1.0) | −3.1 (0.9) | 108 (17.9%) | 118 (19.6%) | ||||
| >20 | 35 | 51.4 (5.0) | −6.7 (4.4) | 4 (11.4%) | 9 (25.7%) | ||||
| Glaucoma | 0.52 | 0.51 | 0.24 | 0.52 | |||||
| No | 579 | 59.1 (1.0) | −3.1 (0.9) | 106 (18.3%) | 118 (20.4%) | ||||
| Yes | 68 | 57.1 (3.0) | −5.0 (2.8) | 8 (11.8%) | 11 (16.2%) | ||||
| CNV in fellow eye | 0.35 | 0.68 | 1.00 | 0.43 | |||||
| None | 460 | 58.5 (1.2) | −3.1 (1.1) | 80 (17.4%) | 95 (20.7%) | ||||
| Present | 170 | 60.5 (1.7) | −4.0 (1.6) | 30 (17.6%) | 30 (17.6%) | ||||
§
From one way analysis of variance for comparing mean VA and VA change from baseline.
┼
From Fisher exact test for comparing percent of gain or loss of ≥3 lines from baseline.
P-value in the parenthesis is from the test of linear trend.
Unknown status for a specific feature was excluded from the univariate analysis for this specific feature.
SE = standard error, VA = visual acuity, CNV = choroid neovascularization, RAP = retinal angiomatous proliferans.