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. Author manuscript; available in PMC: 2019 Mar 1.
Published in final edited form as: Semin Nephrol. 2018 Mar;38(2):175–182. doi: 10.1016/j.semnephrol.2018.01.006

Fig. 2. Tryptophan metabolism favors a grade-dependent increase in immune suppressive metabolites (11 with permission).

Fig. 2

Combined proteomics and metabolomics data of human RCC tissue was overlayed onto a stylized KEGG-based pathway diagram. Green, metabolite; orange, enzyme; black dot arrow, metabolism; red arrow, upregulated pathway; blue arrow, downregulated pathway; MAO, monoamine oxidase; DDC, dopa decarboxylase; ALDH, aldehyde dehydrogenase; IDO, indoleamine 2,3-dioxygenase; TDO, tryptophan 2,3-dioxygenase