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. 2017 Feb 2;32(1):311–330. doi: 10.1080/14756366.2016.1250756

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© 2017 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/Licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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graphic file with name IENZ_A_1250756_F0005a_C.jpg — (A) Docked pose of ZINC02120502 at the active site of PDE6. (B) Docked pose of ZINC02120502 at the active site of PDE11. (C) Overlay of ZINC02120502 (tan) onto the crystal orientation⁶⁵ of tadalafil (blue). (D) Overlay of ZINC16031243 docked poses at the active site of PDE5 (blue), PDE6 (pink) and PDE11 (tan). Protein?ligand interaction diagrams of ZINC02120502 and ZINC16031243 with PDEs (shown in the bottom of the figure).

graphic file with name IENZ_A_1250756_F0005b_C.jpg — (A) Docked pose of ZINC02120502 at the active site of PDE6. (B) Docked pose of ZINC02120502 at the active site of PDE11. (C) Overlay of ZINC02120502 (tan) onto the crystal orientation⁶⁵ of tadalafil (blue). (D) Overlay of ZINC16031243 docked poses at the active site of PDE5 (blue), PDE6 (pink) and PDE11 (tan). Protein?ligand interaction diagrams of ZINC02120502 and ZINC16031243 with PDEs (shown in the bottom of the figure).