Table 1.

PI3Kδ inhibitory activity of 4-pyrrolidineoxy substituted quinazolines ^a .

Compounds	R	PI3Kδ Inhibition (%) b	PI3Kδ IC50 (nM)c
12a		79	ND
12b		90	9.3
12c		96	6.1
12d		98	4.9
12e		53	ND
1	–	96	2.7

^aAll the data are shown as the mean for at least two experiments.

^bPI3Kδ inhibition at the concentration of 100 nM.

^cThe IC₅₀ values for PI3Kδ inhibition.

ND: not detected.