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. 2018 Mar 14;33(1):651–656. doi: 10.1080/14756366.2018.1444608

Table 2.

PI3Kδ inhibitory activity of 4-piperidineamino substituted quinazolines a .

Inline graphic
Compounds R PI3Kδ Inhibition (%) b PI3Kδ IC50 (nM) c
14a graphic file with name IENZ_A_1444608_ILG0008.gif 51 ND
14b graphic file with name IENZ_A_1444608_ILG0009.gif 94 3.0
14c graphic file with name IENZ_A_1444608_ILG0010.gif 91 3.9
14d graphic file with name IENZ_A_1444608_ILG0011.gif 91 8.7
14e graphic file with name IENZ_A_1444608_ILG0012.gif 88 5.2
14f graphic file with name IENZ_A_1444608_ILG0013.gif 54 ND
16a graphic file with name IENZ_A_1444608_ILG0014.gif 72 ND
16b graphic file with name IENZ_A_1444608_ILG0015.gif 70 ND
16c graphic file with name IENZ_A_1444608_ILG0016.gif 48 ND
1 – 96 2.7

aAll the data are shown as the mean for at least two experiments.

bPI3Kδ inhibition at the concentration of 100 nM.

cThe IC50 values for PI3Kδ inhibition.

ND: not detected.