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Isoform selectivity of compounds against PI3K (p110α, p110β, p110γ, and p110δ)
| IC50 (nM)
a
|
||||
|---|---|---|---|---|
| Compounds | p110α | p110β | p110γ | p110δ |
| 12d | 50.4 | 592.5 | 467.6 | 4.9 |
| 14b | 36.6 | 317.2 | 104.0 | 3.0 |
| 14c | 58.9 | 375.9 | 121.1 | 3.9 |
| 1 | 306.4 | 120.1 | 139.4 | 2.7 |
aThe IC50 values are shown as the mean for at least two experiments.
