Table 1.

Physicochemical characterisation data of 2-amino-5-nitrothiazole derived semicarbazones 4–21.

Compound	R1	R2	R3	Mol. Wt. (g mol−1)	M.P. (°C)	Yield (%)	cLogPa	LogPb	Rfc
4	CH3	4-Br	–	384.21	245–247	59.42	3.08	2.2	0.51
5	CH3	4-Cl	–	339.76	144–146	65.84	2.91	2.1	0.49
6	CH3	4-F	–	323.3	267–269	63.92	2.45	1.3	0.47
7	CH3	4-OH	–	321.31	193–195	25.61	2.01	1.2	0.53
8	CH3	4-NO2	–	350.31	292–294	71.25	2.25	1.4	0.46
9	CH2Br	4-Br	–	463.1	123–125	38.23	3.80	–	0.52
10	H	4-Br	–	370.18	287–289	56.71	3.23	2.5	0.48
11	H	4-OH	–	307.29	148–150	49.56	2.16	1.6	0.45
12	H	2,3-Di Cl	–	360.18	>300	61.32	3.67	2.6	0.52
13	H	2,4-Di Cl	–	360.18	232–234	64.51	3.67	2.5	0.56
14	H	2,6-Di Cl	–	360.18	100–102	33.27	3.67	3.1	0.48
15	H	2,5-Di OCH3	–	351.34	276–278	59.42	2.15	–	0.43
16	C6H5	4-H	–	367.38	Charred at 286	51.54	4.21	3.4	0.41
17	C6H5	4-Cl	–	401.83	182–184	48.86	4.82	3.6	0.44
18	C6H5	4-OH	–	383.38	113–115	29.75	3.91	2.9	0.49
19	4-Cl C6H4	4-Cl	–	436.27	>300	58.67	5.42	3.9	0.54
20	–	–	H	332.29	158–160	79.58	1.73	1.1	0.57
21	–	–	Br	411.19	297–299	75.46	2.50	1.9	0.49

^aMarvinSketch 5.6 generated.

^bDetermined by standard octanol/water shake flask method.

^cSolvent system – CHCl₃:CH₃OH:Toluene (7:1:2).