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Hypothetical mode(s) of antimalarial action of 1,2,4-trioxane derivatives. (1) Inhibition of haemoglobin degrading enzyme in food vacuole of parasite, (2) direct lethal action to parasite by LPO process. Pf HDE: P. falciparum haemoglobin degrading enzyme; LPO: lipid peroxidation.
