Table 2.
In vitro antimalarial activity data.
| IC50 in µg/ml (µM)
a
|
||
|---|---|---|
| Comp. | Pf 3D7 | Pf RKL9 |
| 3a | 0.026 (26.20) | 0.028 (28.46) |
| 3b | 0.020 (20.44) | 0.022 (22.26) |
| 3c | 0.16 (160.47) | 0.12 (120.13) |
| 3d | 3.48 (>1000) | 4.09 (>1000) |
| 3e | 3.46 (>1000) | 4.07 (>1000) |
| 3′a | 0.068 (68.46) | 0.066 (66.19) |
| 3′b | 0.0054 (5.43) | 0.0056 (5.68) |
| 3′c | 0.0074 (7.62) | 0.0078 (7.83) |
| 3′d | 0.032 (32.49) | 0.032 (32.54) |
| 3′e | 0.040 (40.78) | 0.036 (36.42) |
| 3′f | 0.052 (52.06) | 0.054 (54.17) |
| 3′g | 0.058 (58.20) | 0.058 (58.34) |
| 3′h | 0.040 (40.21) | 0.036 (36.67) |
| 3′i | 0.074 (74.22) | 0.078 (78.28) |
| 3′j | 0.018 (18.37) | 0.014 (14.72) |
| 3′k | 1.20 (>1000) | 1.48 (>1000) |
| 3′l | 0.0012 (1.24) | 0.0010 (1.06) |
| 3′m | 0.056 (56.09) | 0.064 (64.53) |
| 3′n | 0.045 (45.29) | 0.048 (48.20) |
| 3″a | 2.07 (>1000) | 5.02 (>1000) |
| 3″b | 3.50 (>1000) | 3.61 (>1000) |
| 3″c | 0.22 (220.20) | 0.22 (220.68) |
| 3″d | 0.0012 (1.24) | 0.0011 (1.17) |
| 3″e | 0.0072 (8.27) | 0.0065 (6.52) |
| CQ | 0.0012 (1.23) | 0.147 (47.16) |
a
Calculated using NonLin v1.1 software, mean of two replicate observations (counted against 200 cells per replicate), values in parentheses indicate activity in micromolar (µM) concentration.