Table 3.
Inhibition of Aβ (1–42) self-induced aggregation and ABTS radical by target compounds.
| Compound | R1 | R2 | Aβ (1–42) aggregationinhibition (%)a | ABTS assay(trolox equiv)b |
|---|---|---|---|---|
| 5a | – | – | 46.3 ± 1.6 | Nc |
| 5b | – | 3-CH3 | 48.5 ± 1.8 | N |
| 5c | – | 4-CH3 | 55.1 ± 1.5 | N |
| 5d | – | 3-F | 53.6 ± 2.3 | N |
| 5e | – | 4-F | 52.8 ± 1.8 | N |
| 5f | – | 3-Br | 48.8 ± 2.1 | N |
| 5g | – | 4-Br | 57.2 ± 1.1 | N |
| 5h | 3,4-di-OCH3 | – | 55.7 ± 3.2 | N |
| 5i | 3,4-di-OCH3 | 3-CH3 | 53.9 ± 0.9 | N |
| 5j | 3,4-di-OCH3 | 4-CH3 | 63.4 ± 2.8 | N |
| 5k | 3,4-di-OCH3 | 3-F | 65.6 ± 2.3 | N |
| 5l | 3,4-di-OCH3 | 4-F | 64.7 ± 1.6 | N |
| 5m | 3,4-di-OCH3 | 3-Br | 62.8 ± 1.4 | N |
| 5n | 3,4-di-OCH3 | 4-Br | 66.3 ± 2.9 | N |
| Curcumin | – | – | 54.6 ± 2.6 | 1.65 |
a
Inhibition of Aβ (1–42) self-induced aggregation, the thioflavin-T fluorescence method was used, the mean ± SD of at least three independent experiments and the measurements were carried out in the presence of 20 μM compounds.
b
Data are expressed as (mmol trolox)/(mmol tested compound).
c
N means <0.05.