Table 1.

hIMPDH2 enzyme inhibition of MPA amides (14–28 at 10 µM).

Compound	R	hIMPDH2 enzyme
		% Inhibitiona	IC50 (µM) ± SDb
1	Mycophenolic acid	99.90 ± 1.20	0.25 ± 0.03
14	(S)-(−)-α-Methylbenzyl	59.15 ± 1.91	n.d.c
15	(R)-(+)-α-Methylbenzyl	73.94 ± 2.84	0.82 ± 0.32
16	2-Chlorobenzyl	72.04 ± 1.11	0.73 ± 0.06
17	2-Furfuryl	67.18 ± 4.16	n.d.c
18	4-Methoxybenzyl	96.13 ± 2.51	0.33 ± 0.11
19	4-Methylbenzyl	73.42 ± 3.62	0.60 ± 0.13
20	4-Chlorobenzyl	81.36 ± 1.95	0.57 ± 0.11
21	4-Pyridylmethyl	57.38 ± 1.02	n.d.c
22	2-Pyridylmethyl	59.38 ± 1.81	n.d.c
23	2-Methylbenzyl	84.00 ± 2.13	0.50 ± 0.18
24	4-Phenylbutyl	93.62 ± 3.17	0.48 ± 0.02
25	3,4-(Methylenedioxy)benzyl	87.09 ± 4.54	0.51 ± 0.08
26	2-Morpholinoethyl	36.05 ± 3.86	n.d.c
27	3-Methoxyphenyl	30.82 ± 2.82	n.d.c
28	4-Methoxyphenyl	54.84 ± 1.15	n.d.c

^aAll the data are expressed as ± SD (results are average of duplicate analysis).

^bAll the data are expressed as ± SD (results are average of triplicate analysis). IC₅₀ value was determined when the inhibitory rate of compound is higher than 70% at the concentration of 10 µM.

^cn.d.: not determined.