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. 2018 Feb 27;33(1):546–557. doi: 10.1080/14756366.2018.1437729

Table 3.

IC50 and IC90 of the test compounds 3a,f,g, 4a,b,d,e, 5a,d, 7a, 8a–d,f against MCF-7and A549 cell lines.

  IC50/IC90 (μM)
  MCF-7
A-549
Compound IC50 IC90 IC50 IC90
3a -– 3.52 ± 0.5 25 ± 4
3f 28.79 ± 4
3g 30 ± 2.3 95 ± 11.2  
4a
4b -– 10.94 ± 1.1 26.42 ± 3.1
4d 8.7 ± 0.9 24.8 ± 2
4e
5a 9.6 ± 1.1 27.8 ± 3.1
6a 21 ± 2.1 69 ± 6
6c 39.65 ± 2.1 83.44 ± 5.9  
6d 7.19 ± 1.6 37.57 ± 2.8
7a 33 ± 4.6 60 ± 9.7
8a
8b 14.6 ± 1.9 31.1 ± 2.5
8c 17 ± 2.1 69 ± 8.1
8d
8f
Doxorubicin 2.2 ± 3.1 5.2 ± 1.9 0.087 ± 0.9 0.35 ± 0.7

IC50: Compound concentration required to inhibit the cell viability by 50%; SEM Standard error mean; each value is the mean of three values.