Table 3.
IC50 and IC90 of the test compounds 3a,f,g, 4a,b,d,e, 5a,d, 7a, 8a–d,f against MCF-7and A549 cell lines.
| IC50/IC90 (μM) |
||||
|---|---|---|---|---|
| MCF-7 |
A-549 |
|||
| Compound | IC50 | IC90 | IC50 | IC90 |
| 3a | – | -– | 3.52 ± 0.5 | 25 ± 4 |
| 3f | – | – | 28.79 ± 4 | – |
| 3g | 30 ± 2.3 | 95 ± 11.2 | – | |
| 4a | – | – | – | – |
| 4b | – | -– | 10.94 ± 1.1 | 26.42 ± 3.1 |
| 4d | – | – | 8.7 ± 0.9 | 24.8 ± 2 |
| 4e | – | – | – | – |
| 5a | – | – | 9.6 ± 1.1 | 27.8 ± 3.1 |
| 6a | 21 ± 2.1 | 69 ± 6 | – | – |
| 6c | – | 39.65 ± 2.1 | 83.44 ± 5.9 | |
| 6d | – | – | 7.19 ± 1.6 | 37.57 ± 2.8 |
| 7a | 33 ± 4.6 | 60 ± 9.7 | – | – |
| 8a | – | – | – | – |
| 8b | – | – | 14.6 ± 1.9 | 31.1 ± 2.5 |
| 8c | 17 ± 2.1 | 69 ± 8.1 | – | – |
| 8d | – | – | – | – |
| 8f | – | – | – | – |
| Doxorubicin | 2.2 ± 3.1 | 5.2 ± 1.9 | 0.087 ± 0.9 | 0.35 ± 0.7 |
IC50: Compound concentration required to inhibit the cell viability by 50%; SEM Standard error mean; each value is the mean of three values.