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Percentage of kinases inhibition of compound 5a at (50 and 100 μM).
| Compound 5a |
||
|---|---|---|
| % Inhibition |
||
| Kinase | 50 μM | 100 μM |
| CDK4/CyclinD1 | −35 | −75 |
| EGFR | −81 | −86 |
| PDGFRβ | −82 | −94 |
| PI3K (p110a/p85a) | 181 | 182 |
| PI3K (p110b/p85a) | 473 | 504 |
Negative (−) values: Inhibition of target activity by the compound; Positive (+) value: activation of target activity.
