Table 4.
Compound 5a |
||
---|---|---|
% Inhibition |
||
Kinase | 50 μM | 100 μM |
CDK4/CyclinD1 | −35 | −75 |
EGFR | −81 | −86 |
PDGFRβ | −82 | −94 |
PI3K (p110a/p85a) | 181 | 182 |
PI3K (p110b/p85a) | 473 | 504 |
Negative (−) values: Inhibition of target activity by the compound; Positive (+) value: activation of target activity.