Table 1.

Inhibition of CA isozymes I–XV (of human = h, and murine = m origin) with compounds 1–10.

		KI (μM)a,b
No.	X	hCA I	hCA II	hCA III	hCA IV	hCA VA	hCA VB	hCA VI	hCA VII	hCA IXc	hCA XIIc	mCA XIII	hCA XIV	mCA XV
1	OH	8.65	9.30	6.63	9.10	80.9	79.8	8.80	7.93	9.55	6.45	8.72	8.79	8.03
2	NH2	0.086	0.101	2.26	7.96	1.68	8.82	0.097	0.095	0.097	0.090	0.100	0.092	0.100
3	NHNH2	9.8	5.31	6.28	78.4	7.75	95.2	74.4	8.56	51.7	2.42	5.96	3.81	5.16
4	NHOH	2.73	5.47	4.42	24.6	5.28	67.9	86.2	8.73	60.3	1.53	4.97	1.66	7.17
5	NHOMe	>1000	8.96	5.72	39.5	6.70	10.7	27.0	9.56	64.3	8.32	6.21	1.57	7.84
6	OH	730	30.1	35.7	434	7.12	9.60	91.6	92.2	66.5	20.4	44.8	0.98	72.8
7	NH2	324	93.2	35.7	381	46.8	83.1	82.6	76.8	3.67	11.2	45.1	27.0	85.5
8	NHNH2	91.2	231	40.2	335	59.3	75.9	63.5	76.7	48.4	45.0	44.4	0.99	94.2
9	NHOH	83.1	179	44.8	84.7	67.4	53.6	78.1	70.7	45.9	9.51	23.0	0.94	79.9
10	NHOMe	72.5	341	37.3	111	89.1	57.3	89.9	72.2	57.5	28.5	63.3	10.0	106

^aErrors in the range of ±5% of the reported data from three different assays.

^bh = human; m = murine isozyme.

^cCatalytic domain.