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. 2017 Dec 22;33(1):271–285. doi: 10.1080/14756366.2017.1414807

Scheme 2.

Scheme 2.

Synthesis of novel 7-deazapurine with N-1 substituted 1,2,3-triazole. Reagents and conditions: (i) propargyl bromide, K2CO3/NaH DMF, Ar atmosphere, 60 °C, 24 h; (ii) corresponding azide, Cu, 1 M CuSO4 solution, tert-butanol: H2O = 1: 1, MW 300 W, 80 °C, 45 min.