Table 1.

The growth-inhibition effects in vitro of synthesised compounds on selected tumour and normal cell lines.

			IC50 a (µM)
Compounds	Purine or pseudopurine	R	A549	CFPAC-1	HeLa	SW620	WI38/HFF-1 b	ClogP c
4a			53.22	33.39	34.21	38.94	5.21	2.68
4c			15.91	7.90	12.30	14.69	0.75	3.44
4d			54.65	31.10	33.21	41.75	23.88	2.68
4e			88.95	>100	57.96	92.50	6.58	1.68
5c			9.43	7.39	22.52	11.77	5.21	3.29
5d			73.86	>100	>100	90.25	23.89	2.53
5e			>100	>100	>100	>100	60.49	1.53
6e			>100	>100	>100	>100	73.63	2.14
7c			>100	89.24	36.80	68.95	19.43	3.29
7e			>100	>100	8.77	>100	7.62	1.53
8a			85.36	48.37	39.41	8.50	32.18	3.44
8b			64.52	47.69	65.46	44.64	21.02	3.84
8c			46.91	46.55	38.83	37.05	4.62	4.20
8d			69.02	35.19	83.32	65.45	22.53	3.44
8e			69.19	36.27	33.59	73.48	39.93	2.44
9c			66.36	62.77	32.89	55.74	57.54	5.03
9d			86.36	65.10	20.03	65.90	48.47	4.27
9e			45.45	47.30	24.50	45.09	10.78	3.27
10a			>100	>100	>100	>100	>100	3.89
10b			40.16	>100	31.01	45.84	58.07	4.29
10c			71.57	64.71	53.01	54.25	24.03	4.65
10d			>100	>100	82.92	>100	>100	3.89
10e			51.93	77.08	47.63	57.55	45.70	2.89
11a			44.01	>100	>100	43.29	>100 b	3.95
11b			>100	>100	>100	>100	>100 b	4.41
11c			>100	>100	>100	>100	>100 b	4.68
11d			51.27	85.56	71.15	44.83	40.42 b	3.95
11e			75.38	>100	83.01	68.49	40.00 b	3.17
12a			76.26	86.52	71.70	99.92	91.91	3.14
12b			0.79	52.55	42.17	91.23	38.10	3.60
12c			14.18	56.43	30.61	>100	>100	3.87
12d			36.25	34.68	21.94	>100	30.63	3.14
12e			>100	>100	>100	>100	>100	2.35

^a50% inhibitory concentration or compound concentration required inhibiting tumour cell proliferation by 50%.

^bCompounds 11a–e were tested in HFF-1 cell line.

^cValues of n-octanol/water partition coefficients logP were calculated using ChemAxon algorithm (MarvinView Ver. 6.2.2.).