Table 1.

Protein kinase inhibitory activity as determined K_i values of our target compounds 5a–h, 6a–c and 7 for the tyrosine receptor kinases EGFR and IGF-1R.

	Ki values [μM]
Compound	EGFR	IGF-1R
5a	0.344 ± 0.024	9.84 ± 0.238
5z	0.361 ± 0.035	3.47 ± 0.071
5c	0.255 ± 0.018	2.96 ± 0.037
5d	0.101 ± 0.011	0.537 ± 0.022
5e	1.17 ± 0.057	2.23 ± 0.022
5f	n.a.*	2.29 ± 0.043
5g	0.448 ± 0.072	0.884 ± 0.025
5h	0.279 ± 0.091	0.697 ± 0.015
6a	0.072 ± 0.017	0.288 ± 0.026
6b	0.158 ± 0.026	0.269 ± 0.022
6c	0.160 ± 0.015	0.390 ± 0.016
7	0.140 ± 0.028	2.36 ± 0.132

*Not active.