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. 2017 Jan 23;32(1):496–503. doi: 10.1080/14756366.2016.1265518

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© 2017 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Scheme 1. — Synthesis of inhibitors 3, 4, and 5. EDC = N-(3-dimethylaminopropyl)-N'-ethylcarbodiimide hydrochloride; HOBt = hydroxybenzotriazole hydrate; TFA = trifluoroacetic acid; Boc = tert-butoxycarbonyl; y = yield.