Table 2.

Inhibition constants of neohesperidin dihydrochalcone, rutin and phloretin for the reduction of L-idose or HNE obtained through a computer assisted simulation at different DMSO concentrations.

			Ki (µM)			Ki′ (µM)
Substrate	Inhibitor	Inhibition model	DMSO 40 mM	DMSO 100 mM	DMSO 200 mM	DMSO 40 mM	DMSO 100 mM	DMSO 200 mM
L-idose	NHDC	Mixed	109	133	172	292	292	292
HNE	NHDC	Uncompetitive	–	–	–	135	155	187
L-idose	Rutin	Mixed	20.8	25.4	33.0	9.3	9.3	9.3
HNE	Rutin	Uncompetitive	–	–	–	10.2	11.6	14.1
			–	–	–
L-idose	Phloretin	Mixed	77.9	95.0	123.3	52.5	52.5	52.5
HNE	Phloretin	Mixed	69.6	83.3	105.9	62.5	71.5	86.4