Table 1.

Results of pim-1 kinase inhibition achieved by the test compounds.

Compound number	R or Ar	% Inhibition at 25µM	IC50 (µM)
3a	4-C6H5CH2OC6H4	83	0.96
3b	4-BrC6H4	96	0.06
3c	4-ClC6H4	92	0.14
3d	2,4-(OH)2C6H3	81	1.34
3e	3,4-(OH)2C6H3	93	0.06
3f	4-FC6H4	89	1.00
3g	3-OCH3-4-OHC6H3	92	0.08
3h	4-OCH3C6H4	84	1.17
3i	3,4,5-(OCH3)3C6H2	81	0.93
3j	3-Thienyl	95	0.10
6	H	81	1.08
7a	CH3	76	1.76
7b	CF3	93	0.08
8	CH2COOC2H5	95	0.10
9a	4-BrC6H4	88	0.52
9b	2-CF3C6H4	89	0.22
Staurosporine	–	94	Not determined