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. 2017 Nov 8;33(1):74–84. doi: 10.1080/14756366.2017.1376666

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© 2017 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 4. — Effects of compound 2 on EGFR and aurora kinases in growing SCCHN cell lines (A) Western blot analysis of EGFR (pEGFR, pERK, p-AKT) and aurora A (p-HH3) downstream target proteins following incubation with 100 μM compound 2 for the indicated time points in BHY and FADU SCCHN cell lines. (B) BHY and CAL cell lines treated for the indicated time points with 200 nM cetuximab. Western blot analysis of EGFR downstream targets. (long exposure and short exposure). (C) FADU and SAS SCCHN cell lines incubated with 10 nM MLN8237 and 5 nM R736 showed inhibition of histone H3 phosphorylation. Western blot analysis of p-HH3 at the indicated time points. Asterisk (*) represents unspecific band.