Table 3.

Inhibitory activities towards hMAO-A and hMAO-B of EMAC II (i–m) derivatives.

Compound	Structure	MAO-A (IC50)	MAO-B (IC50)	Ratioe
EMAC II i		b	104.04 ± 3.69 nM	>961d
EMAC II j		b	41.05 ± 1.52 nM	>2436d
EMAC II k		b	320.22 ± 13.61 nM	>312d
EMAC II l		b	11.97 ± 0.37 nM	>8354d
EMAC II m		b	449.57 ± 18.02 nM	>222d
Clorgiline		4.46 ± 0.32 nMc	61.35 ± 1.13 μM	0.000073
l-Deprenyl		67.25 ± 1.02 μMc	19.60 ± 0.86 nM	3431.12
Iproniazide		6.56 ± 0.76 μM	7.54 ± 0.36 μM	0.87
Moclobemide		361.38 ± 19.37 μM	a	<0.36e

^aInactive at 1 mM (highest concentration tested).

^bInactive at 100 μM (highest concentration tested). At higher concentration, the compounds precipitate.

^cResults are mean ± SEM from five experiments. Level of statistical significance: ^cP <0.01 versus the corresponding IC₅₀ values obtained against MAO-B, as determined by ANOVA/Dunnett’s.

^dValues obtained under the assumption that the corresponding IC₅₀ against MAO-A is the highest concentration tested (100 μM).

^eSelectivity ratios [IC₅₀(MAO-A)]/[IC₅₀(MAO-B)].