Table 2.
1H NMR data of derivatives EMAC 3039–3064.
| Compound | 1H NMR |
|---|---|
| EMAC 3039 | 1H NMR (CDCl3) δ(ppm): 8.29 (d, 1H) (dm; J = 7.48 Hz; 1H); 8.10 (s; 1H); 7.49 (d, 1H) (dm, J = 7.95 Hz; 1H); 7.36 (d, 1H); (dm; J = 8.03 Hz; 1H); 7.24 (s, 1H); 7.04 (t, 1H) (dm; J = 7.60 Hz; 1H); 6.89 (d, 1H) (dm; J = 7.64 Hz; 1H); 6.31 (s, 1H); 3.58 (s, 3H). |
| EMAC 3040 | 1H NMR (DMSO-d6) δ(ppm): 10.48 (s, 1H); 8.22 (d; 1H) (dm, J = 7.39 Hz; 1H); 7.64 (dt, 1H) (dm, J = 5.35, 8.25 Hz; 1H); 7.49 (d, 1H) (dm, J = 7.45 Hz; 1H); 7.38 (td, 1H) (dm; J = 1.63,8.74 Hz; 1H); 7.25 (td, 1H) (dm, J = 1.48, 7.69 Hz; 1H); 6.99 (q, 1H) (dm, J = 7.20 Hz; 1H); 6.84 (m, 1H); 3.50 (s, 3H). |
| EMAC 3041 | 1H NMR (DMSO-d6) δ(ppm): 10.48 (s, 1H); 8.22 (d, 1H) (dm, J = 7.54 Hz; 1H); 7.74 (d, 1H) (dm, J = 8.43 Hz; 1H); 7.54 (d, 1H) (dm; J = 8.12 Hz; 1H); 7.47 (d, 1H) (dm, J = 7.01 Hz; 1H); 7.24 (m, 1H); 6.98(dt, 1H) (dm, J = 7.61, 15.13 Hz; 1H); 6.83(m, 1H); 3.53 (s, 3H). |
| EMAC 3042 | 1H NMR (CDCl3) δ(ppm): 8.38 (d, 1H) (dm, J = 8.20 Hz; 1H); 8.29 (d, 1H) (dm, J = 7.54 Hz; 1H); 7.63 (d, 1H) (dm, J = 8.23 Hz; 1H); 7.50 (s, 1H); 7.26 (m, 1H); 7.06 (t, 1H) (dm; J = 7.36 Hz; 1H); 6.86 (d, 1H) (dm; J = 7.84 Hz; 1H); 6.46 (s, 1H); 3.63 (s, 3H). |
| EMAC 3043 | 1H NMR (DMSO-d6) δ(ppm): 10.56 (s, 1H); 8.24 (d, 1H) (dm, J = 7.52 Hz; 1H); 7.83 (dd, 1H) (dm, J = 4.30,8.21 Hz; 1H); 7.75 (m, 1H); 7.68 (dd, 1H) (dm, J = 5.55,7.98 Hz; 1H); 7.50 (m, 1H); 7.42 (t, 1H) (dm, J = 7.37 Hz; 1H); 7.25 (m, 1H); 7.00 (dt, 1H); (dm, J = 7.51, 12.06 Hz; 1H); 6.89 (t, 1H) (dm, J = 9.92 Hz; 1H); 6.84 (t, 1H) (dm; J = 7.75, 18.98 Hz; 1H); 3.57 (s, 3H). |
| EMAC 3044 | 1H NMR (DMSO-d6) δ(ppm): 10.51 (s, 1H); 8.22 (d, 1H); (dm, J = 7.46 Hz; 1H); 8.01 (dd, 1H) (dm, J = 6.34,8.30 Hz; 1H); 7.81 (dd, 1H) (dm, J = 5.59, 8.10 Hz; 1H); 7.47 (d, 1H); (dm, J = 7.29 Hz; 1H); 7.25(m, 1H); 7.00(m, 1H); 6.85(m, 1H); 3.42 (s, 3H). |
| EMAC 3045 | 1H NMR (CDCl3) δ(ppm): 8.47(s, 1H); 8.29 (d, 1H) (dm; J = 7.51 Hz; 1H); 7.40 (q, 1H) (dm, J = 7.86 Hz; 1H); 7.25 (m, 1H); 7.04 (m, 1H); 6.99 (m, 1H); 6.91(d, 1H); (dm, J = 7.68 Hz; 1H); 6.37(s, 1H); 3.52 (s, 3H). |
| EMAC 3046 | 1H NMR (DMSO-d6) δ(ppm): 1052 (s, 1H); 8.39 (s, 1H); 8.36 (dm, 1H); 8.05 (d, J = 8 Hz; 1H); 7.83 (t, J = 8; 1H); 7.47 (d, J = 7.5 Hz; 1H); 7.23 (t, J = 7.5 Hz; 1H); 7.01 (s, 1H); 6.97 (t, J = 7.5 Hz; 1H); 6.80 (d, J = 8 Hz; 1H); 3.52 (s, 3H). |
| EMAC 3047 | 1H NMR (DMSO-d6) δ(ppm): 10.49 (s, 1H); 8.22 (d, 1H) (dm, J = 7.56 Hz; 1H); 7.91(dd, 1H) (dm, J = 2.06, 6.23 Hz; 1H); 7.81 (dd, 1H) (dm, J = 7.19,8.31 Hz; 1H); 7.60 (ddd, 1H) (dm, J = 2.10, 5.88, 8.30 Hz; 1H); 7.47 (d, 1H) (dm, J = 7.39 Hz; 1H); 7.23(m, 1H); 6.97(m, 1H); 6.80(d, 1H) (dm; J = 7.79 Hz; 1H); 3.51 (s, 3H). |
| EMAC 3048 | 1H NMR (CDCl3) δ(ppm): 8.30 (m, 1H); 8.11 (s, 1H); 7.86(s, 1H); 7.30 (q, 1H); 7.24 (dd, 3H); (dm, J = 1.35, 7.69 Hz; 1H); 7.04 (m, 1H); 6.88(d, 1H); 6.28(s, 1H); 6.37(s, 1H); 3.52 (s, 3H). |
| EMAC 3049 | 1H NMR (CDCl3) δ(ppm): 8.30 (d, 1H); (dm, J = 7.54 Hz; 1H); 7.94 (s, 1H); 7.34(s, 1H) (dm, J = 8.77 Hz; 1H); 7.24 (m, 1H); 7.05 (d, 1H) (dm, J = 7.49 Hz; 1H); 7.01 (m, 1H) (dm, J = 8.75 Hz; 1H); 6.86 (d, 1H) (dm, J = 7.66 Hz; 1H); 6.25(s, 1H); 3.88 (s, 3H); 3.58 (s, 3H). |
| EMAC 3050 | 1H NMR (CDCl3) δ(ppm): 8.30(d, 1H); (dm, J = 7.42 Hz; 1H); 7.98(s, 1H); 7.50 (q, 1H) (dm, J = 3.69 Hz; 1H); 7.42 (dd, 1H) (dm, J = 2.97, 6.43 Hz; 1H); 7.25 (t, 1H); (dm, J = 7.83 Hz; 1H); 7.05 (t, 1H) (dm, J = 7.42 Hz; 1H); 6.88 (d, 1H) (dm, J = 7.64 Hz; 1H); 6.31 (s, 1H); 3.60 (s, 3H). |
| EMAC 3051 | 1H NMR (CDCl3) δ(ppm): 8.29 (d, 1H) (dm, J = 7.45 Hz; 1H); 7.75 (s, 1H); 7.57(d, 1H) (dm, J = 10.05 Hz; 1H); 7.41 (d, 1H) (dm, J = 8.48 Hz; 1H); 7.35 (d, 1H) (dm, J = 8.18 Hz; 1H); 7.24 (d, 1H) (dm, J = 6.97 Hz; 1H); 7.04 (d, 1H) (dm, J = 7.55 Hz; 1H); 6.86 (d, 1H) (dm, J = 7.75 Hz; 1H); 6.35 (s, 1H); 3.46 (s, 3H). |
| EMAC 3052 | 1H NMR (CDCl3) δ(ppm): 8.27(d, 1H) (dm, J = 2.16 Hz; 1H); 7.99 (s, 1H); 7.50 (d, 1H) (dm, J = 8.55 Hz; 1H); 7.37 (d, 1H) (dm, J = 8.49 Hz; 1H); 7.22 (dd, 1H) (dm, J = 2.19, 8.30 Hz; 1H); 6.81 (d, 1H) (dm, J = 8.33 Hz; 1H); 6.36 (s, 1H); 3.61 (s, 3H). |
| EMAC 3053 | 1H NMR (CDCl3) δ(ppm): 8.28(s, 1H); 7.63 (d, 1H) (dm, J = 17.38 Hz; 1H); 7.49 (s, 1H); 7.41 (m, 1H); 7.20 (q, 1H) (dm, J = 8.33 Hz; 1H); 6.79 (d, 1H) (dm, J = 8.32 Hz; 1H); 6.35 (s, 1H); 3.58 (s, 3H); NH not detected |
| EMAC 3054 | 1H NMR (CDCl3) δ(ppm): 8.28 (d, 1H) (dm, J = 2.22 Hz; 1H); 7.65 (t; 1H) (dm; J = 9.12 Hz; 1H); 7.30 (dd, 1H) (dm, J = 6.98, 8.73 Hz; 1H); 7.22 (dd, 1H) (dm, J = 2.20, 8.26 Hz; 1H); 6.80 (d, 1H) (dm, J = 8.26 Hz; 1H); 6.37 (s, 1H); 3.61 (s, 3H); NH not detected. |
| EMAC 3055 | 1H NMR (CDCl3) δ(ppm): 8.39 (d, 1H) (d, J = 8.67 Hz; 1H); 8.28 (s, 1H); 7.64 (m, 1H); 7.49 (s, 1H); 7.24 (d, 1H) (dm; J = 12.22 Hz; 1H); 6.79 (m, 1H); 6.49 (d, 1H) (dm; J = 16.75 Hz; 1H); 3.65 (s, 3H). |
| EMAC 3056 | 1H NMR (CDCl3) δ(ppm): 8.30 (d, 1H); (d, J = 2.21 Hz; 1H); 8.18 (s, 1H); 7.73(d, 1H) (dm, J = 8.17 Hz; 1H); 7.65 (d, 1H) (dm, J = 7.55 Hz; 1H); 7.50 (d, 1H) (dm, J = 7.86 Hz; 1H); 7.41 (t, 1H) (dm; J = 7.29Hz; 1H); 7.21 (m; 1H); 6.83 (d, 1H) (dm, J = 8.21 Hz; 1H); 6.76 (d, 1H) (dm, J = 8.22 Hz; 1H); 6.41 (s, 1H); 3.68 (s, 3H). |
| EMAC 3057 | 1H NMR (DMSO) δ(ppm): 10.61 (s, 1H); 8.18 (d. 1H) (dm, J = 2.25 Hz; 1H); 8.02(dd, 1H) (dm, J = 6.72, 8.38 Hz; 1H); 7.82 (dd, 1H) (dm, J = 6.17, 8.23 Hz; 1H); 7.28 (ddd, 1H) (dm, J = 2.24, 8.22, 26.39 Hz; 1H); 7.04 (s, 1H); 6.84 (dd, 1H) (dm, J = 8.26, 29.93 Hz; 1H); 3.54 (s, 3H). |
| EMAC 3058 | 1H NMR (DMSO) δ(ppm): 10.63 (s, 1H); 8.17 (d, 1H) (dm, J = 2.21 Hz; 1H); 7.68(qd, 1H) (dm, J = 6.35, 8.53 Hz; 1H); 7.53 (tdd, 1H), (dm, J = 2.46, 7.91, 10.16 Hz; 1H); 7.31 (ddt, 1H) (dm, J = 2.76, 5.70, 11.48 Hz; 1H); 7.02 (s, 1H); 6.87 (d, 1H) (dm, J = 8.28 Hz; 1H); 6.81(d, 1H) (dm, J = 8.29 Hz; 1H); 3.47 (s, 3H). |
| EMAC 3059 | 1H NMR (CDCl3) δ(ppm): 8.38 (d, 1H); (d, J = 8.38 Hz; 1H); 7.79 (d; 1H) (dm, J = 7.58 Hz; 1H); 7.74 (t, 1H) (dm, J = 8.02 Hz; 1H); 7.67 (s, 1H); 7.24 (dd, 1H) (dm, J = 2.07, 8.08 Hz; 1H); 6.80 (d, 1H) (dm, J = 8.29 Hz; 1H); 6.75 (d, 1H) (dm, J = 8.27 Hz; 1H); 6.49 (s; 1H); 3.65 (s, 1H). |
| EMAC 3060 | 1H NMR (CDCl3) δ(ppm): 8.27 (d, 1H); (d, J = 2.11 Hz; 1H); 7.92 (s, 1H); 7.60 (d, 1H) (dm, J = 8.37 Hz; 1H); 7.55 (s, 1H); 7.27 (m, 1H); 6.81 (d, 1H) (dm, J = 8.29 Hz; 1H); 6.40 (s, 1H); 3.62 (s, 1H). |
| EMAC 3061 | 1H NMR (DMSO) δ(ppm): 10.60 (s, 1H); 8.17 (s, 1H); 7.47 (d, J = 8 Hz; 2H); 7.34 (d, J = 8 Hz; 2H); 7.29 (d, J = 8 Hz; 1H); 6.85 (d, J = 8 Hz; 1H); 3.56 (s, 3H); 3.29 (s, 3H). |
| EMAC 3062 | 1H NMR (DMSO) δ(ppm): 10.60 (s, 1H); 8.18 (d, 1H) (dm, J = 2.15 Hz; 1H); 7.52(d, 1H) (dm, J = 8.54 Hz; 1H); 7.29 (dd, 1H); (dm, J = 2.22, 8.28 Hz; 1H); 7.09 (d, 1H) (dm, J = 8.53 Hz; 1H); 6.86 (d, 1H) (dm, J = 8.29 Hz; 1H); 6.81 (s, 1H); 3.83 (s, 3H); 3.57 (s, 3H). |
| EMAC 3063 | 1H NMR (CDCl3) δ(ppm): 8.29 (d, 1H) (d; J = 2.14 Hz; 1H); 7.69 (s; 1H); 7.51 (m, 1H); 7.43 (m, 1H); 7.21(m, 1H); 6.79 (d, 1H); (dm, J = 8.25 Hz; 1H); 6.37 (s, 1H); 3.63 (s, 1H); NH not detected. |