Table 5.
Multivariate regression model for BPD
| BPD (N = 317) | No BPD (N = 606) | OR (95% CI) | p-Value | Adjusted OR (95% CI) | Model p-value | |
|---|---|---|---|---|---|---|
| BW (g) | 795 (189) | 976 (181) | 0.3 (0.2–0.4) | < 0.001 | 0.7a (0.5–0.9) | 0.002 |
| GA (wk) | 25.9 (1.8) | 28.1 (2.1) | 0.6 (0.5–0.6) | < 0.001 | 0.8 (0.7–0.9) | < 0.001 |
| Race | ||||||
| White | 177 (55.8) | 290 (47.9) | Ref | – | Ref | – |
| Black | 75 (23.7) | 150 (24.8) | 0.8 (0.6–1.1) | 0.24 | 0.8 (0.5–1.2) | 0.20 |
| Others | 65 (20.5) | 166 (27.4) | 0.6 (0.5–0.9) | 0.01 | 0.8 (0.5–1.1) | 0.17 |
| MV ≥ 48 h | 270 (85.2) | 244 (40.3) | 8.5 (6.0–12.1) | < 0.001 | 2.1 (1.4–3.3) | < 0.001 |
| Any HFVa | 157 (49.3) | 71 (11.7) | 7.4 (5.3–10.3) | < 0.001 | 2.8 (1.9–4.1) | < 0.001 |
| Late-onset sepsis | 119 (37.5) | 93 (15.4) | 3.3 (2.4–4.6) | < 0.001 | 1.6 (1.1–2.4) | 0.01 |
| CMV positive | 14 (4.4) | 5 (0.8) | 6.4 (2.3–18.0) | < 0.001 | 4.0 (1.3–12.4) | 0.02 |
Abbreviations: BPD, bronchopulmonary dysplasia; BW, birth weight; CI, confidence interval; CMV, cytomegalovirus; GA, gestational age; HFV, high-frequency ventilation; MV, mechanical ventilation; OR, odds ratio; Ref, reference value.
Note: Model includes all infants with birth weight < 1,250 g, born from 2003 to 2013 with clinical status known at 36 weeks CGA (N = 923). Postnatal steroid treatment was given in 37 (11.8%) of BPD patients versus 10 (1.7%) of infants without BPD (p < 0.001). This variable was excluded from the final model due to collinearity with BPD as outcome.
a
Odds ratio for increase per 250 g birth weight.