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. 2016 Oct 25;32(1):78–83. doi: 10.1080/14756366.2016.1235568

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© 2016 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/Licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 3. — (A) Inhibitory activity of compound 9 on tyrosinase (IC_50: 9.8 ± 0.9 μM; kojic acid =19.5 ± 1.5 μM). (B) Relationship of the hydrolytic activity of tyrosinase with enzyme concentration at a variety of inhibitor concentration. (C) Lineweaver–Burk plot (Competitive type) and (D) Dixon plot (K_i: 5.8 ± 0.9 μM) for the inhibition of compound 9.